Sung OK Yoon PhD


Sung OK Yoon PhD
Assoc ProfessorCollege of Medicineyoon.84@osu.edu
184 Rightmire Hall 1060 Carmack Road Columbus Ohio 43210
Phone:614-292-8542Fax: 614-292-5379
  • Molecular Biology and Cancer Genetics

General Research Interest

JNK signaling, polarity in glioma invasion, Alzheimer's disease

Research Description

The long-term goal of Dr. Yoon's lab is to understand how the balance between cell survival and death is maintained in the adult nervous system.  Currently, they are focusing on the role of stress kinase, JNK signaling, under pathological conditions.

Transinstitutional Work

In collaboration with Drs. M. Viapiano and C.H. Kwon, we are investigating the role of small GTPase and polarity proteins in glioma invasion. 

Current Publications

  • Kim TH, Song J, Kim SH, Parikh AK, Mo X, Palanichamy K, Kaur B, Yu J, Yoon SO, Nakano I, Kwon CHPiperlongumine treatment inactivates peroxiredoxin 4, exacerbates endoplasmic reticulum stress, and preferentially kills high-grade glioma cells.Neuro Oncol in press 5/30/2014
  • Tian J, Tep C, Zhu MX, Yoon SOChanges in Spontaneous firing patterns of cerebellar Purkinje cells in p75 knockout mice.Cerebellum 12 300-3 6/1/2013
  • Limpert AS, Bai S, Narayan M, Wu J, Yoon SO, Carter BD, Lu QRNF-κB forms a complex with the chromatin remodeler BRG1 to regulate Schwann cell differentiation.J Neurosci 33 2388-97 2/6/2013
  • Tep C, Lim TH, Ko PO, Getahun S, Ryu JC, Goettl VM, Massa SM, Basso M, Longo FM, Yoon SOOral administration of a small molecule targeted to block proNGF binding to p75 promotes myelin sparing and functional recovery after spinal cord injury.J Neurosci 33 397-410 1/9/2013
  • Yoon SO, Park DJ, Ryu JC, Ozer HG, Tep C, Shin YJ, Lim TH, Pastorino L, Kunwar AJ, Walton JC, Nagahara AH, Lu KP, Nelson RJ, Tuszynski MH, Huang KJNK3 perpetuates metabolic stress induced by Aβ peptides.Neuron 75 824-37 9/6/2012

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu