Susan Cole E PhD


Susan Cole E PhD
Assoc ProfessorCollege of Arts & Sciencescole.354@osu.edu
282 Bioscience Building 484 W 12th Avenue Columbus Ohio 43210
Phone:614-292-3276Fax: (614) 292-4466
  • Molecular Biology and Cancer Genetics

General Research Interest

Roles of fringe genes and Notch signaling during development and in disease.

Research Description

The Notch signaling pathway plays key roles in human development and disease.  Disregulation of Notch signaling is frequently seen in human cancers, for instance, activating Notch mutations are seen in over 50% of juvenille T-ALL cases.  Lunatic fringe (Lfng) is a key modulator of Notch signaling and, during development, links it to a cellular clock that times somitogenesis.  One major focus of our research is to understand the transcriptional and post-transcriptional mechanisms that control the oscillatory activity of Lfng in the segmentation clock. This research provides key insights into more general mechanisms that control the spatial and temporal activation of the Notch pathway. In other projects we are analyzing other functions of fringe family proteins during development and in disease. Disregulation of Notch signaling is found in numerous cancers. By focusing on the regulation of Lfng activity and its ability to modulate Notch signaling, we will gain a deeper understanding of the importance of signaling modulation during normal cellular development, and how disruption of these processes may be involved in cancer.

Transinstitutional Work

We have established collaborative projects with laboratories at several other universities (Dr. Groves, House Ear Institute; Dr. Schwarting, University of Massachusetts Medical School; Dr. Loomes, University of Pennsylvania School of Medicine) to examine diverse functions of fringe genes during development. In addition, in an ongoing collaboration with Dr. Kim McBride at Nationwide Children's Hospital we are examining the mechanisms by which missense mutations in the human Notch1 gene may lead to left ventricular outflow tract defects in patients.

Current Publications

  • Wahi K, Bochter MS, Cole SEThe many roles of Notch signaling during vertebrate somitogenesis.Semin Cell Dev Biol in press 12/4/2014
  • Nandhu MS, Hu B, Cole SE, Erdreich-Epstein A, Rodriguez-Gil DJ, Viapiano MSNovel Paracrine Modulation of Notch-DLL4 Signaling by Fibulin-3 Promotes Angiogenesis in High-Grade Gliomas.Cancer Res in press 8/19/2014
  • Miller AJ, Cole SEMultiple Dlk1 splice variants are expressed during early mouse embryogenesis.Int J Dev Biol 58 65-70 1/1/2014
  • Riley MF, Bochter MS, Wahi K, Nuovo GJ, Cole SEMir-125a-5p-mediated regulation of Lfng is essential for the avian segmentation clock.Dev Cell 24 554-61 3/11/2013

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 460 W. 10th Avenue, Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu