Bruce Aronow PhD


Bruce Aronow PhD
ProfessorCollege of Medicine--UCbruce.aronow@cchmc.org
S.10.248 240 Albert Sabin Way Cincinnati OH 45229
Phone:513-636-4865Fax: 513-636-2056
  • Molecular Biology and Cancer Genetics

General Research Interest

Systems biology of oncogenesis and malignancy.  Prediction of drug targets and optimal therapeutics based on integrative knowledge analysis of individual cancers oncogenome.

Research Description

Dr. Aronow's research efforts are directed to the goal of bringing complete knowledge of gene functions and gene activity to the analysis disease mechanisms.  To do this he works with investigators in many different areas of research to use technologies that measure gene activity and gene variation and mutation across the whole genome. His group works on the analysis of data and the development of databases that help researchers to predict active pathways of cancer based on gene expression analyses using gene expression and gene variation -sensitive microarrays and next-generation sequencing technologies.  He is now working on the development of new database system that uses extensive knowledge and data that profiles drug sensitivities of different cancers to help predict the powerful therapeutic agents against different cancers.

Transinstitutional Work

Dr. Aronow is collaborating with several investigators from the James and the The Research Institute at Nationwide Children's Hospital in order to understand the molecular basis of colon cancer malignancy and the regulation of gene expression and differentiation of stem cells.

Current Publications

  • Gardner JC, Noel JG, Nikolaidis NM, Karns R, Aronow BJ, Ogle CK, McCormack FXG-CSF drives a posttraumatic immune program that protects the host from infection.J Immunol 192 2405-17 3/1/2014
  • Myronovych A, Kirby M, Ryan KK, Zhang W, Jha P, Setchell KD, Dexheimer PJ, Aronow B, Seeley RJ, Kohli RVertical sleeve gastrectomy reduces hepatic steatosis while increasing serum bile acids in a weight-loss-independent manner.Obesity (Silver Spring) 22 390-400 2/1/2014
  • Velu CS, Chaubey A, Phelan JD, Horman SR, Wunderlich M, Guzman ML, Jegga AG, Zeleznik-Le NJ, Chen J, Mulloy JC, Cancelas JA, Jordan CT, Aronow BJ, Marcucci G, Bhat B, Gebelein B, Grimes HLTherapeutic antagonists of microRNAs deplete leukemia-initiating cell activity.J Clin Invest 124 222-36 1/2/2014
  • Akdemir KC, Jain AK, Allton K, Aronow B, Xu X, Cooney AJ, Li W, Barton MCGenome-wide profiling reveals stimulus-specific functions of p53 during differentiation and DNA damage of human embryonic stem cells.Nucleic Acids Res 42 205-23 1/1/2014
  • Zhu C, Wu C, Aronow BJ, Jegga AGComputational approaches for human disease gene prediction and ranking.Adv Exp Med Biol 799 69-84 1/1/2014
  • Unruh D, Turner K, Srinivasan R, Kocatürk B, Qi X, Chu Z, Aronow BJ, Plas DR, Gallo CA, Kalthoff H, Kirchhofer D, Ruf W, Ahmad SA, Lucas FV, Versteeg HH, Bogdanov VYAlternatively spliced tissue factor contributes to tumor spread and activation of coagulation in pancreatic ductal adenocarcinoma.Int J Cancer 134 9-20 1/1/2014
  • Habli M, Jones H, Aronow B, Omar K, Crombleholme TMRecapitulation of characteristics of human placental vascular insufficiency in a novel mouse model.Placenta 34 1150-8 12/1/2013
  • Su S, Saldanha R, Pemberton A, Bangar H, Kawamoto SA, Aronow B, Hassett DJ, Lamkin TJCharacterization of stable, constitutively expressed, chromosomal green and red fluorescent transcriptional fusions in the select agent bacterium, Francisella tularensis Schu S4 and the surrogate type B live vaccine strain (LVS).Appl Microbiol Biotechnol 97 9029-41 10/1/2013
  • Harari-Steinberg O, Metsuyanim S, Omer D, Gnatek Y, Gershon R, Pri-Chen S, Ozdemir DD, Lerenthal Y, Noiman T, Ben-Hur H, Vaknin Z, Schneider DF, Aronow BJ, Goldstein RS, Hohenstein P, Dekel BIdentification of human nephron progenitors capable of generation of kidney structures and functional repair of chronic renal disease.EMBO Mol Med 5 1556-68 10/1/2013
  • Osterburg AR, Hexley P, Supp DM, Robinson CT, Noel G, Ogle C, Boyce ST, Aronow BJ, Babcock GFConcerns over interspecies transcriptional comparisons in mice and humans after trauma.Proc Natl Acad Sci U S A 110 E3370 9/3/2013
  • Chatterjee TK, Aronow BJ, Tong WS, Manka D, Tang Y, Bogdanov VY, Unruh D, Blomkalns AL, Piegore MG, Weintraub DS, Rudich SM, Kuhel DG, Hui DY, Weintraub NLHuman coronary artery perivascular adipocytes overexpress genes responsible for regulating vascular morphology, inflammation, and hemostasis.Physiol Genomics 45 697-709 8/15/2013
  • Noah TK, Lo YH, Price A, Chen G, King E, Washington MK, Aronow BJ, Shroyer NFSPDEF functions as a colorectal tumor suppressor by inhibiting β-catenin activity.Gastroenterology 144 1012-1023.e6 5/1/2013
  • Sun S, Wang W, Latchman Y, Gao D, Aronow B, Reems JAExpression of plasma membrane receptor genes during megakaryocyte development.Physiol Genomics 45 217-27 3/18/2013
  • Lu TX, Lim EJ, Besse JA, Itskovich S, Plassard AJ, Fulkerson PC, Aronow BJ, Rothenberg MEMiR-223 deficiency increases eosinophil progenitor proliferation.J Immunol 190 1576-82 2/15/2013
  • Jessen WJ, Miller SJ, Jousma E, Wu J, Rizvi TA, Brundage ME, Eaves D, Widemann B, Kim MO, Dombi E, Sabo J, Hardiman Dudley A, Niwa-Kawakita M, Page GP, Giovannini M, Aronow BJ, Cripe TP, Ratner NMEK inhibition exhibits efficacy in human and mouse neurofibromatosis tumors.J Clin Invest 123 340-7 1/2/2013
  • Subramani A, Alsidawi S, Jagannathan S, Sumita K, Sasaki AT, Aronow B, Warnick RE, Lawler S, Driscoll JJThe brain microenvironment negatively regulates miRNA-768-3p to promote K-ras expression and lung cancer metastasis.Sci Rep 3 2392 1/1/2013
  • Phelan JD, Saba I, Zeng H, Kosan C, Messer MS, Olsson HA, Fraszczak J, Hildeman DA, Aronow BJ, Möröy T, Grimes HLGrowth factor independent-1 maintains Notch1-dependent transcriptional programming of lymphoid precursors.PLoS Genet 9 e1003713 1/1/2013
  • Lu TX, Lim EJ, Itskovich S, Besse JA, Plassard AJ, Mingler MK, Rothenberg JA, Fulkerson PC, Aronow BJ, Rothenberg METargeted ablation of miR-21 decreases murine eosinophil progenitor cell growth.PLoS One 8 e59397 1/1/2013
  • Grande A, Sumiyoshi K, López-Juárez A, Howard J, Sakthivel B, Aronow B, Campbell K, Nakafuku MEnvironmental impact on direct neuronal reprogramming in vivo in the adult brain.Nat Commun 4 2373 1/1/2013
  • van Berlo JH, Aronow BJ, Molkentin JDParsing the roles of the transcription factors GATA-4 and GATA-6 in the adult cardiac hypertrophic response.PLoS One 8 e84591 1/1/2013
  • Wu C, Gudivada RC, Aronow BJ, Jegga AGComputational drug repositioning through heterogeneous network clustering.BMC Syst Biol 7 Suppl 5 S6 1/1/2013
  • Patel AV, Eaves D, Jessen WJ, Rizvi TA, Ecsedy JA, Qian MG, Aronow BJ, Perentesis JP, Serra E, Cripe TP, Miller SJ, Ratner NRas-driven transcriptome analysis identifies aurora kinase A as a potential malignant peripheral nerve sheath tumor therapeutic target.Clin Cancer Res 18 5020-30 9/15/2012

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu