Jeffrey Parvin MD, PhD


Jeffrey Parvin MD, PhD
ProfessorCollege of Medicineparvin.4@osu.edu
3190 Graves Hall 333 W 10th Avenue Columbus Ohio 43210
Phone:614-292-0523Fax:
  • Molecular Biology and Cancer Genetics

General Research Interest

breast cancer, systems biology, molecular biology

Research Description

Research in the Parvin lab focuses on the biological processes involved in breast cancer.  We focus on pathways regulated by the BRCA1 and BRCA2 tumor suppressor proteins, and these include the repair of DNA damage, control of transcription, control of cell cycle progression, and centrosome control.  We use a variety of methods that include the use of informatics to generate hypotheses and biochemical and molecular biology experiments using tissue culture models.

Transinstitutional Work

As Director of the Biomedical Shared Resource, Dr. Parvin collaborates with a number of OSU labs in the analysis of data-intensive experiments, such as gene expression analysis and next-generation sequence analysis.  The Parvin laboratory collaborates with the Huang and Catalyurek groups to develop new informatics methods for deriving biologically useful hypotheses that can be tested in the laboratory.  The laboratory collaborates with breast cancer physicians in order to develop new antibody-based biomarker methods for the evaluation of breast cancer cases.  The Parvin laboratory is also in the Tumor Microenvironment program.

Current Publications

  • Parvin JNUSAP1 influences the DNA damage response by controlling BRCA1 protein levels.Cancer Biol Ther 15 2/12/2014
  • Zhang DBRCA1 promotes the ubiquitination of PCNA and recruitment of translesion polymerases in response to replication blockade.Proc Natl Acad Sci U S A 110(33) 8/13/2013
  • Wang J, Lan X, Hsu PY, Hsu HK, Huang K, Parvin J, Huang TH, Jin VXGenome-wide analysis uncovers high frequency, strong differential chromosomal interactions and their associated epigenetic patterns in E2-mediated gene regulation.BMC Genomics 14 70 1/31/2013
  • Zhang J, Ni S, Xiang Y, Parvin J, Yang Y, Zhou Y, Huang KGene Co-expression analysis predicts genetic aberration loci associated with colon cancer metastasis.Int J Comput Biol Drug Des 6(1-2) 60-71 1/1/2013
  • Arora M, Zhang J, Heine GF, Ozer G, Liu HW, Huang K, Parvin JPromoters active in interphase are bookmarked during mitosis by ubiquitination.Nucleic Acids Res 40(20) 10187-202 11/1/2012
  • Liu HW, Zhang J, Heine GF, Arora M, Gulcin Ozer H, Onti-Srinivasan R, Huang K, Parvin JChromatin modification by SUMO-1 stimulates the promoters of translation machinery genes.Nucleic Acids Res 40(20) 10172-86 11/1/2012

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu