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Chang-hyuk Kwon PhD


Chang-hyuk Kwon PhD
Asst ProfessorCollege of Medicinechang-hyuk.kwon@osumc.edu
820 BRT 460 W 12th Avenue Columbus OH 43210
Phone:614-688-5867Fax:
  • Molecular Biology and Cancer Genetics

General Research Interest

Mouse models of glioblastoma, cancer stem cells, identification of tumor driver, cellular origin of glioma, PTEN signaling in the brain 

Research Description

My laboratory is studying glioblastoma, the most aggressive and common brain malignancy with poor prognosis. By using Nf1, Trp53 and Pten conditional deletion in the brain, we have generated physiologically relevant mouse genetic models of this devastating disease. We also have demonstrated that a majority of the brain tumor type originates from neural stem cell lineage. By culturing the origin and tumor cells in neurosphere and monitoring molecular and cellular changes during the tumor development, we are searching for tumor drivers responsible for glioblastoma formation. 

Current Publications

  • Guvenc H, Pavlyukov MS, Joshi K, Kurt H, Banasavadi-Siddegowda YK, Mao P, Hong C, Yamada R, Kwon C, Bhasin D, Chettiar S, Kitange G, Park IH, Sarkaria JN, Li C, Shakhparonov MI, Nakano IImpairment of glioma stem cell survival and growth by a novel inhibitor for Survivin-Ran protein complex.Clin Cancer Res 19(3) 631-42 2/1/2013
  • Price RL, Bingmer K, Harkins L, Iwenofu OH, Kwon C, Cook C, Pelloski CE, Chiocca EACytomegalovirus infection leads to pleomorphic rhabdomyosarcomas in Trp53 +/- mice.Cancer Res in press 9/21/2012
  • Kim TH, Song J, Alcantara Llaguno SR, Murnan E, Liyanarachchi S, Palanichamy K, Yi JY, Viapiano MS, Nakano I, Yoon SO, Wu H, Parada LF, Kwon CSuppression of peroxiredoxin 4 in glioblastoma cells increases apoptosis and reduces tumor growth.PLoS One 7(8) e42818 1/1/2012