Research DescriptionDr. Kitagawa's research involves the role that the spindle checkpoint plays in tumor development. Mutations in genes required for kinetochore function and mitotic checkpoint surveillance possibly contribute development of cancer.
His lab is employing a series of genetic and biochemical strategies to identify additional interacting gene products, regulators, and potential substrates of Sgt1/Skp1/Hsp90 action in yeast and vertebrates. In studies with human cells, they have found a novel mechanism by which 17-AAG (an Hsp90 inhibitor and a novel anti-cancer drug) inhibits cell proliferation and provide the first evidence of HSP90 being required for assembly of kinetochore protein complexes in humans.