Lei Cao PhD

Lei Cao PhD
Assoc ProfessorCollege of Medicinecao.76@osu.edu
914 Biomedical Research Tower 460 W 12th Avenue Columbus Ohio 43210
Phone:614-247-2792Fax: (614) 292-6356
  • Molecular Biology and Cancer Genetics

General Research Interest

understanding the physical, social environment and mental state influence physiological processes with a particular focus on the CNS control of metabolism, adipose tissue remodeling, and cancer

Research Description

Dr. Cao’s lab has characterized a novel brain-fat axis (hypothalamic-sympathoneural-adipocyte axis) underlying the anti-obesity and anticancer phenotypes associated with a complex environment using multidisciplinary approaches to further define this neuroendocrine axis, identify molecular mediators, and develop both genetic and pharmacological approaches to combat obesity, metabolic syndromes, and cancer.

Current Publications

  • Liu X, McMurphy T, Xiao R, Slater A, Huang W, Cao LHypothalamic gene transfer of BDNF inhibits breast cancer progression and metastasis in middle age obese mice.Mol Ther 22 1275-84 7/1/2014
  • Liu X, Magee D, Wang C, McMurphy T, Slater A, During M, Cao LAdipose tissue insulin receptor knockdown via a new primate-derived hybrid recombinant AAV serotype.Mol Ther Methods Clin Dev 1 2/5/2014
  • McMurphy T, Xiao R, Magee D, Slater A, Zabeau L, Tavernier J, Cao LThe anti-tumor activity of a neutralizing nanobody targeting leptin receptor in a mouse model of melanoma.PLoS One 9 e89895 1/1/2014

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 460 W. 10th Avenue, Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu