Ioanna Papandreou PhD

Res Asst ProfessorCollege of MedicineIoanna.Papandreou@osumc.edu

524 Tzagournis MRF 420 W 12th Avenue Columbus OH 43210

Phone:614-685-6910Fax:

Molecular Biology and Cancer Genetics

General Research Interest

Microenvironmental determinants of tumor metabolism and growth.

Research Description

The dysfunctional tumor vasculature and the deregulated cancer cell proliferation create areas of oxygen- and nutrient- deprivation in solid tumors. Cells within the tumor respond to these microenvironmental stresses by activating adaptive mechanisms that allow malignant progression under such harsh conditions. Dr. Papandreou is investigating stress-modulated transcriptional and biochemical pathways, with particular emphasis given to the reprogramming of glucose and lipid metabolism under hypoxic environments. Her research employs in vitro models of hypoxia and hypoglycemia, tumor xenotransplantation protocols and genetically engineered mouse models with the goal to identify new targets for therapeutic development.

Current Publications

Sayers CM, Papandreou I, Guttmann DM, Maas NL, Diehl JA, Witze ES, Koong AC, Koumenis CIdentification and characterization of a potent activator of p53-independent cellular senescence via a small-molecule screen for modifiers of the integrated stress response.Mol Pharmacol 83(3) 594-604 3/1/2013