Christin E Burd PhD

Asst. ProfessorCollege of Arts and Sciencesburd.25@osu.edu

586 BRT 460 W 12th Avenue Columbus OH 43210

Phone:614-292-8084Fax: 614-688-4245

Molecular Biology and Cancer Genetics

General Research Interest

The Role of the INK4/ARF locus in cancer and aging

Research Description

The INK4/ARF locus encodes three tumor suppressor genes frequently lost or silenced in human cancers (p15INK4b, p16INK4a, and p14ARF). We aim to faithfully recapitulate the genetics of these tumors through the development of genetically engineered mouse models. In addition, we have pioneered in vivo imaging techniques that allow us to track the formation and progression of spontaneous cancers. Use of these technologies will provide mechanistic insight into the molecular processes governing tumor initiation, progression and therapeutic resistance. It is our goal to bridge the gap between bench science and clinical trials, generating faithful models for drug discovery and efficacy studies.

Current Publications

Burd CE, Sorrentino JA, Clark KS, Darr DB, Krishnamurthy J, Deal AM, Bardeesy N, Castrillon DH, Beach DH, Sharpless NEMonitoring tumorigenesis and senescence in vivo with a p16(INK4a)-luciferase model.Cell 152(1-2) 340-51 1/17/2013