Ashish Kumar MD, PhD

Ashish Kumar MD, PhD
Asst ProfessorCollege of Medicine - UCashish.kumar@cchmc.orgwebsite
7015 MLC 3333 Burnet Avenue Cincinnati OH 45229
Phone:(513) 803-2994Fax: (513) 636-3549
  • Molecular Biology and Cancer Genetics

General Research Interest

Dr. Kumar’s laboratory is engaged in researching the biology of infant leukemia. Discoveries made in his laboratory have significantly enhanced the current understanding of leukemia.

Research Description

Dr. Kumar's research studies the biology of infant-leukemia to identify novel therapeutic approaches to treat this disease. Infants with leukemia face an exceptionally grim prognosis because the pathogenesis of the disease is different than that seen in older children. Majority of leukemia in infants involve translocations of the MLL gene on chromosome 11q23. Dr. Kumar's lab is studying experimental models of MLL-rearranged leukemia in the laboratory to discover biological pathways that are dysregulated in the leukemic cells. In knock-in MLL-AF9 mice, they have identified several genes that are abnormally upregulated in hematopoietic cells compared to corresponding wild type cells. These genes and pathways are also up-regulated in leukemia cells of human patients. The lab is now studying the role of these activated genes in the pathogenesis of leukemia.

Current Publications

  • Kumar AR, Geha RS, Douek DC, Holland SM, Freeman AF, Su HC, Jing H, Zhang Q, Zhang Y, Hill BJ, Dove CG, Gelfand EW, Atkinson TP, Uzel G, Matthews HF, Mustillo PJ, Lewis DB, Kavadas FD, Hanson ICSomatic reversion in dedicator of cytokinesis 8 immunodeficiency modulates disease phenotype.J Allergy Clin Immunol 133 1667-75 6/1/2014
  • Liu X, Chhipa RR, Pooya S, Wortman M, Yachyshin S, Chow LM, Kumar A, Zhou X, Sun Y, Quinn B, McPherson C, Warnick RE, Kendler A, Giri S, Poels J, Norga K, Viollet B, Grabowski GA, Dasgupta BDiscrete mechanisms of mTOR and cell cycle regulation by AMPK agonists independent of AMPK.Proc Natl Acad Sci U S A 111 E435-44 1/28/2014
  • Karkare S, Chhipa RR, Anderson J, Liu X, Henry H, Gasilina A, Nassar N, Roychoudhury J, Clark JP, Kumar A, Pauletti GM, Ghosh PK, Dasgupta BDirect inhibition of retinoblastoma phosphorylation by nimbolide causes cell-cycle arrest and suppresses glioblastoma growth.Clin Cancer Res 20 199-212 1/1/2014

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 460 W. 10th Avenue, Columbus, OH 43210 Phone: 1-800-293-5066 | Email: