Ruoning Wang PhD


Ruoning Wang PhD
Asst ProfessorCollege of Medicineruoning.wang@nationwidechildrens.org
WA5016 700 Children's Drive Columbus OH 43205
Phone:(614) 355-2980Fax: (614) 722-5895
  • Molecular Biology and Cancer Genetics

General Research Interest

Cancer biology and Immunology

Research Description

The fundamental interest of Dr. Wang's labe is to understand how eukaryotic cell integrates various extracellular and intrinsic signals/cues to dictate cellular fate (cell proliferation, death, growth and differentiation). In particular, we focus on understanding the impact of the interplay between cell metabolic programs and cell signaling programs on cell fate determination in the context of tumorigenesis and immunity. We apply various experimental models, each one of these has unique scientific features, to address our questions. To name few, the mouse models of human tumor and autoimmune disease (accessible for genetic and pharmacological modulations), frog oocytes (with defined cell cycle stage and accessible for direct intracellular injection of biological material), various primary cells from mouse (MEFs, T, B cell and macrophage) and human transformed cell lines (provide unique cellular tools to understand the potential cellular mechanisms that may mimic what happen in vivo).

Current Publications

  • Caro-Maldonado A, Wang R, Nichols AG, Kuraoka M, Milasta S, Sun LD, Gavin AL, Abel ED, Kelsoe G, Green DR, Rathmell JCMetabolic reprogramming is required for antibody production that is suppressed in anergic but exaggerated in chronically BAFF-exposed B cells.J Immunol 192 3626-36 4/15/2014
  • Zhang Z, Chu Y, Yang R, Liu G, Bi Y, Wang R, Yang H, Zhang Y, Wang X, Liu H, Lu Y, Chen WTargeting S1P1 receptor protects against murine immunological hepatic injury through myeloid-derived suppressor cells.J Immunol 192 3068-79 4/1/2014
  • Wang T, Liu G, Wang RThe Intercellular Metabolic Interplay between Tumor and Immune Cells.Front Immunol 5 358 1/1/2014
  • Tait SW, Oberst A, Quarato G, Milasta S, Haller M, Wang R, Karvela M, Ichim G, Yatim N, Albert ML, Kidd G, Wakefield R, Frase S, Krautwald S, Linkermann A, Green DRWidespread mitochondrial depletion via mitophagy does not compromise necroptosis.Cell Rep 5 878-85 11/27/2013

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu