Tsonwin Hai PhD


Tsonwin Hai PhD
ProfessorCollege of Medicinehai.2@osu.edu
174 Rightmire Hall 1060 Carmack Road Columbus Ohio 43210
Phone:614-292-2910Alternate Phone:(614) 292-2916Fax: (614) 292-5379
  • Molecular Biology and Cancer Genetics

General Research Interest

Molecular mechanisms of human diseases, Stress responses and inflammation in disease context, Breast cancer, melanoma, and diabetes

Research Description

Maladaptation of cells to various signals plays important roles in the pathogenesis of many diseases.  The current focus of my laboratory is to study the maladaptive processes in the development of breast cancer, melanoma, and diabetes.  In all three cases, inflammatory signals exacerbate the diseases.  We are investigating how inflammatory signals in conjunction with other stress signals affect various cellular machineries that regulate signal transduction, gene expression, apoptosis, cell migration, angiogenesis, metastasis, and cell-cell interactions. The approach we take is to focus on a stress-inducible gene ATF3, which encodes a member of the ATF/CREB transcription factors and functions as a “hub” of the cellular adaptive-response networks. Our strategy is to use ATF3 — as a handle — to probe the stress responses and gain insights to the roles of cellular adaptations to stress signals in the development of above diseases. For more information, see http://cmn.osu.edu/1493.cfm. 

Transinstitutional Work

We are collaborating with various investigators both at the Ohio State University (OSU) and outside of OSU.  Current collaborations include: At OSU - Drs. Sudha Agarwal, William Carson, Sissy Jhiang, Marino Leon, Michael Ostrowski, Charles Shapiro for cancer research and Drs. Jianjun Guan, Gregg Hadley, Douglas McCarty, Amer Rajab for islet transplantation and gene targeting using adeno-associated viruses. Outside of OSU - Drs. Marc Montminy at the Salk Institute, Mirmira Raghu at University of Indiana, Ling Qi at Cornell University, Decio Eizirik and Miriam Cnopp at Universite Libre de Bruxelles for islet biology and diabetes

Current Publications

  • Boespflug ND, Kumar S, McAlees JW, Phelan JD, Grimes HL, Hoebe K, Hai T, Filippi MD, Karp CLATF3 is a novel regulator of mouse neutrophil migration.Blood 123 2084-93 3/27/2014
  • Kline CF, Wright PJ, Koval OM, Zmuda EJ, Johnson BL, Anderson ME, Hai T, Hund TJ, Mohler PJβIV-Spectrin and CaMKII facilitate Kir6.2 regulation in pancreatic beta cells.Proc Natl Acad Sci U S A 110 17576-81 10/22/2013
  • Zmuda EJ, O'Toole SA, Millar EK, Roller SL, Shapiro CL, Ostrowski MC, Sutherland RL, Hai T, Wolford CC, McConoughey SJ, Jalgaonkar SP, Leon M, Merchant AS, Dominick JL, Yin X, Chang YTranscription factor ATF3 links host adaptive response to breast cancer metastasis.J Clin Invest 123 2893-906 7/1/2013
  • Koren L, Elhanani O, Kehat I, Hai T, Aronheim AAdult cardiac expression of the activating transcription factor 3, ATF3, promotes ventricular hypertrophy.PLoS One 8 e68396 1/1/2013

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu