Sissy M Jhiang PhD


Sissy M Jhiang PhD
ProfessorCollege of Medicinejhiang.1@osu.edu
210 Hamilton Hall 1645 Neil Avenue Columbus Ohio 43210
Phone:614-292-4312Fax: 614-292-4888
  • Molecular Biology and Cancer Genetics

General Research Interest

genetic-engineered mouse models for thyroid tumorigenesis, anatomic/functional imaging in pre-clinical mouse models, sodium-iodide symporter targeted imaging and radionuclide therapy in thyroid cancer and breast cancer, mechanobiology during cancer metastasis.

Research Description

Dr Jhiang current research interests are: (a) examine RET/PTC mediated signaling pathways in thyroid tumorigenesis and apply the finding to improve patients' care; (b) Investigate regulatory mechanisms of Na+/I- symporter(NIS) in thyroid cancer and breast cancer and apply the finding to develop strategies for radionuclide imaging and effective targeted therapy; (c) NIS as an imaging reporter gene to monitor gene delivery in gene therapy clinical trials; and (d) mechanobiology characterization in the process of cancer metastasis using one-of-the-kind instruments based on atomic force microscopy, magnetic tweezer, and photonic force microscopy (in collaboration with Dr. CH Menq at the Department of Mechanical Engineering). Thus, Dr. Jhiang's research areas involved in molecular biology, cellular biology, genetic engineered animal models, small animal imaging modalities, and nanobiotechnology.

Transinstitutional Work

thyroid cancer animal models as well as sodium iodide symporter DNA construcs have been requested by multiple institutes nationally and internationally. active collaborations within OSU: (1) thyroid cancer NCI funded program project, and (b) mechanobiology in cancer metastasis

Current Publications

  • Jhiang SMApigenin in Combination with Akt Inhibition Significantly Enhances Thyrotropin-Stimulated Radioiodide Accumulation in Thyroid Cells.Thyroid 3/6/2014
  • Laperle KM, Kim DC, Hall NC, Bobbey A, Shen DH, Nagy R, Wakely Jr PE, Lehman A, Jarjoura D, Jhiang SMModulation of sodium/iodide symporter expression in the salivary gland.Thyroid 23(8) 1029-36 8/1/2013
  • Brandt MP, Kloos RT, Shen DH, Zhang X, Liu YY, Jhiang SMMicro-single-photon emission computed tomography image acquisition and quantification of sodium-iodide symporter-mediated radionuclide accumulation in mouse thyroid and salivary glands.Thyroid 22(6) 617-24 6/1/2012
  • Liu YY, Zhang X, Ringel MD, Jhiang SModulation of sodium iodide symporter expression and function by LY294002, Akti-1/2 and Rapamycin in thyroid cells.Endocr Relat Cancer 19(3) 291-304 6/1/2012

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu