General Research Interestgenetic-engineered mouse models for thyroid tumorigenesis, anatomic/functional imaging in pre-clinical mouse models, sodium-iodide symporter targeted imaging and radionuclide therapy in thyroid cancer and breast cancer, mechanobiology during cancer metastasis.
Research DescriptionDr Jhiang current research interests are: (a) examine RET/PTC mediated signaling pathways in thyroid tumorigenesis and apply the finding to improve patients' care; (b) Investigate regulatory mechanisms of Na+/I- symporter(NIS) in thyroid cancer and breast cancer and apply the finding to develop strategies for radionuclide imaging and effective targeted therapy; (c) NIS as an imaging reporter gene to monitor gene delivery in gene therapy clinical trials; and (d) mechanobiology characterization in the process of cancer metastasis using one-of-the-kind instruments based on atomic force microscopy, magnetic tweezer, and photonic force microscopy (in collaboration with Dr. CH Menq at the Department of Mechanical Engineering). Thus, Dr. Jhiang's research areas involved in molecular biology, cellular biology, genetic engineered animal models, small animal imaging modalities, and nanobiotechnology.
Transinstitutional Workthyroid cancer animal models as well as sodium iodide symporter DNA construcs have been requested by multiple institutes nationally and internationally. active collaborations within OSU: (1) thyroid cancer NCI funded program project, and (b) mechanobiology in cancer metastasis