Ronald Glaser PhD

Ronald Glaser PhD
ProfessorCollege of
120C Behavioral Med Res Inst 460 Medical Center Drive Columbus OH 43210
Phone:(614) 293-0178Fax: (614) 292-1011
  • Cancer Control

Research Description

Ronald Glaser is a tumor virologist who has studied Epstein-Barr Virus (EBV) and cancer for several years. He has focused primarily on viral latency and the replication of EBV in epithelial cells in order to help understand the role that EBV plays in the etiology of nasopharyngeal carcinoma (NPC). He also works closely with Dr. Janice Kiecolt-Glaser studying the interactions between the central nervous system, the immune system and the endocrine system, how stress modulates these systems and the health implications of these interactions. His work has focused on stress and herpesvirus latency, vaccine responses, wound healing and the role that stress may play as a co-factor in the etiology and progression of malignant disease.

Transinstitutional Work

In a study published in Cancer Research (Eric Yang, Anil Sood, Min Chen, Yang Li, Timothy Eubank, Clay Marsh, Scott Jewell, Nicholas Flavahan, Carl Morrison, Peir-En Yeh, Stanley Lemeshow, and Ronald Glaser, Cancer Research, 2006), we showed that nasopharyngeal carcinoma (NPC) tumor cells express beta-adrenergic receptors. When two NPC tumor cell lines were treated with norepinephrine or epinephrine, two stress hormones produced by activation of the sympathetic-adrenal medullary axis, the production of matrix metalloproteinases (MMP)-2, MMP-9 and vascular endothelial growth factor (VEGF) was up-regulated. We also showed that this had functional implications for tumor progression and that tumor cells in NPC biopsies express beta adrenergic receptors; these data suggest clinical relevance. In a follow-up study (Eric Yang, Seung-jae Kim, Elise Donovan, Min Chen, Amy Gross, Jeanette Webster-Marketon, Sanford Barsky and Ronald Glaser, Brain, Behavior and Immunity, 2009), we found that the C8161 melanoma cell line also expresses beta-adrenergic receptors. When treated with the same stress hormones, VEGF was up-regulated along with two cytokines that play a role in the growth of melanoma tumors in vivo, IL-6 and IL-8. We have also shown that 18 out of 20 melanoma biopsies (both primary and metastatic) express the beta-adrenergic receptors, again supporting the possibility that these data may have clinical relevance. Similar results were obtained with multiple myeloma tumor cell lines as well. (Eric Yang, Elise Donovan, Don Benson, and Ronald Glaser, Brain, Behavior and Immunity, 2008) This exciting line of research shows that stress hormones can modulate and enhance tumor progression of distinctly different tumor types, such as carcinomas and melanomas. It is clear that other studies need to be done on other tumor cell types as well, but the applicability of using beta-blocker type drugs in patients whose tumors express beta-adrenergic receptors in a clinical setting may be worth exploring.

Current Publications

  • Kiecolt-Glaser JK, Glaser R, Christian LMOmega-3 Fatty acids and stress-induced immune dysregulation: implications for wound healing.Mil Med 179 129-33 11/1/2014
  • Derry HM, Jaremka LM, Bennett JM, Peng J, Andridge R, Shapiro C, Malarkey WB, Emery CF, Layman R, Mrozek E, Glaser R, Kiecolt-Glaser JKYoga and self-reported cognitive problems in breast cancer survivors: a randomized controlled trial.Psychooncology in press 10/21/2014
  • Fagundes CP, Jaremka LM, Glaser R, Alfano CM, Povoski SP, Lipari AM, Agnese DM, Yee LD, Carson WE 3rd, Farrar WB, Malarkey WB, Chen M, Kiecolt-Glaser JKAttachment anxiety is related to Epstein-Barr virus latency.Brain Behav Immun 41 232-8 10/1/2014
  • Jaremka LM, Belury MA, Andridge RR, Malarkey WB, Glaser R, Christian L, Emery CF, Kiecolt-Glaser JKInterpersonal stressors predict ghrelin and leptin levels in women.Psychoneuroendocrinology 48 178-88 10/1/2014
  • Aubrecht TG, Weil ZM, Ariza ME, Williams M, Reader BF, Glaser R, Sheridan JF, Nelson RJEpstein-Barr virus (EBV)-encoded dUTPase and chronic restraint induce impaired learning and memory and sickness responses.Physiol Behav in press 18-24 7/15/2014
  • Stowe RP, Ruiz RJ, Fagundes CP, Stowe RH, Chen M, Glaser RAn ELISA method to compute endpoint titers to Epstein-Barr virus and cytomegalovirus: Application to population-based studies.J Immunol Methods 408 64-9 6/1/2014
  • Hughes S, Jaremka LM, Alfano CM, Glaser R, Povoski SP, Lipari AM, Agnese DM, Farrar WB, Yee LD, Carson WE 3rd, Malarkey WB, Kiecolt-Glaser JKSocial support predicts inflammation, pain, and depressive symptoms: longitudinal relationships among breast cancer survivors.Psychoneuroendocrinology 42 38-44 4/1/2014
  • Kiecolt-Glaser JK, Bennett JM, Andridge R, Peng J, Shapiro CL, Malarkey WB, Emery CF, Layman R, Mrozek EE, Glaser RYoga's impact on inflammation, mood, and fatigue in breast cancer survivors: a randomized controlled trial.J Clin Oncol 32 1040-9 4/1/2014
  • Ariza ME, Glaser R, Williams MVHuman herpesviruses-encoded dUTPases: a family of proteins that modulate dendritic cell function and innate immunity.Front Microbiol 5 504 1/1/2014
  • Glaser M, Iveson P, Hoppmann S, Indrevoll B, Wilson A, Arukwe J, Danikas A, Bhalla R, Hiscock DThree methods for 18F labeling of the HER2-binding affibody molecule Z(HER2:2891) including preclinical assessment.J Nucl Med 54 1981-8 11/1/2013
  • Jaremka LM, Glaser R, Malarkey WB, Kiecolt-Glaser JKMarital distress prospectively predicts poorer cellular immune function.Psychoneuroendocrinology 38 2713-9 11/1/2013
  • Derry HM, Fagundes CP, Andridge R, Glaser R, Malarkey WB, Kiecolt-Glaser JKLower subjective social status exaggerates interleukin-6 responses to a laboratory stressor.Psychoneuroendocrinology 38 2676-85 11/1/2013
  • Kiecolt-Glaser JK, Jaremka LM, Derry HM, Glaser RTelomere length: a marker of disease susceptibility?Brain Behav Immun 34 29-30 11/1/2013
  • Jaremka LM, Fagundes CP, Glaser R, Bennett JM, Malarkey WB, Kiecolt-Glaser JKLoneliness predicts pain, depression, and fatigue: understanding the role of immune dysregulation.Psychoneuroendocrinology 38 1310-7 8/1/2013
  • Fagundes CP, Glaser R, Hwang BS, Malarkey WB, Kiecolt-Glaser JKDepressive symptoms enhance stress-induced inflammatory responses.Brain Behav Immun 31 172-6 7/1/2013
  • Jaremka LM, Fagundes CP, Peng J, Bennett JM, Glaser R, Malarkey WB, Kiecolt-Glaser JKLoneliness promotes inflammation during acute stress.Psychol Sci 24 1089-97 7/1/2013
  • Hosang GM, Johnson SL, Kiecolt-Glaser J, Di Gregorio MP, Lambert DR, Bechtel MA, Hearne DW, Herron JB, Glaser RGender specific association of child abuse and adult cardiovascular disease in a sample of patients with basal cell carcinoma.Child Abuse Negl 37 374-9 6/1/2013
  • Fagundes CP, Glaser R, Malarkey WB, Kiecolt-Glaser JKChildhood adversity and herpesvirus latency in breast cancer survivors.Health Psychol 32 337-44 3/1/2013
  • Jaremka LM, Glaser R, Loving TJ, Malarkey WB, Stowell JR, Kiecolt-Glaser JKAttachment anxiety is linked to alterations in cortisol production and cellular immunity.Psychol Sci 24 272-9 3/1/2013
  • Andridge RR, Peng J, Malarkey WB, Kiecolt-Glaser JK, Bennett JM, Glaser RLong lasting effects of smoking: breast cancer survivors' inflammatory responses to acute stress differ by smoking history.Psychoneuroendocrinology 38 179-87 2/1/2013
  • Kiecolt-Glaser JK, Epel ES, Belury MA, Andridge R, Lin J, Glaser R, Malarkey WB, Hwang BS, Blackburn EOmega-3 fatty acids, oxidative stress, and leukocyte telomere length: A randomized controlled trial.Brain Behav Immun 28 16-24 2/1/2013
  • Fagundes CP, Glaser R, Kiecolt-Glaser JKStressful early life experiences and immune dysregulation across the lifespan.Brain Behav Immun 27 8-12 1/1/2013
  • Ariza ME, Rivailler P, Glaser R, Chen M, Williams MVEpstein-Barr virus encoded dUTPase containing exosomes modulate innate and adaptive immune responses in human dendritic cells and peripheral blood mononuclear cells.PLoS One 8 e69827 1/1/2013
  • Johannesdottir SA, Schmidt M, Phillips G, Glaser R, Yang EV, Blumenfeld M, Lemeshow SUse of ß-blockers and mortality following ovarian cancer diagnosis: a population-based cohort study.BMC Cancer 13 85 1/1/2013
  • Binkley PF, Cooke GE, Lesinski A, Taylor M, Chen M, Laskowski B, Waldman WJ, Ariza ME, Williams MV Jr, Knight DA, Glaser REvidence for the role of Epstein Barr Virus infections in the pathogenesis of acute coronary events.PLoS One 8 e54008 1/1/2013

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