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Thomas J. Rosol DVM, PhD

Thomas J. Rosol DVM, PhD
ProfessorCollege of Veterinary Medicinerosol.1@osu.edu
307 Goss Laboratory 1925 Coffey Road Columbus OH 43210
Phone:614-292-4265Fax: 614-292-6473
  • Molecular Carcinogenesis and Chemoprevention

Research Description

Thomas Rosol, DVM, PhD is a veterinary pathologist in the Department of Veterinary Biosciences. The Rosol Laboratory is NCI and NCRR-funded to develop mouse models of human cancer with emphasis on bone metastasis, bone resorption and formation, and cancer-associated hypercalcemia. The molecular regulation of parathyroid hormone-related protein (PTHrP) is studied in vitro and in vivo using animal models of prostate, lung, breast, and head & neck cancer, and lymphoma and PTHrP knockout mice. Both breast and prostate cancer metastasize to bone in humans, but breast cancer typically induces osteolytic disease and prostate cancer typically induces osteoblastic metastases. The Rosol laboratory has developed mouse models of breast and prostate cancer that mimic the metastases in humans and are used to investigate the pathogenesis and treatment of metastasis. Models of metastasis include intracardiac, intratibial, and orthotopic injections of tumor cells. Laboratory personnel include the PI, assistant professors, research scientist, post-professional PhD students, and undergraduate students. Laboratory expertise has been developed for in vivo imaging of cancer in mouse models using bioluminescence from luciferase-transduced cancer cells. The lab is also collaborating to examine the ability of nanoparticles to enhance the ultrasound imaging of cancer molecular markers. 

Current Publications

  • Martin CK, Dirksen WP, Carlton MM, Lanigan LG, Pillai SP, Werbeck JL, Simmons JK, Hildreth BE 3rd, London CA, Toribio RE, Rosol TJCombined zoledronic acid and meloxicam reduced bone loss and tumour growth in an orthotopic mouse model of bone-invasive oral squamous cell carcinoma.Vet Comp Oncol in press 5/8/2013
  • Sneh A, Deol YS, Ganju A, Shilo K, Rosol TJ, Nasser MW, Ganju RKDifferential role of psoriasin (S100A7) in estrogen receptor α positive and negative breast cancer cells occur through actin remodeling.Breast Cancer Res Treat 138(3) 727-39 4/1/2013
  • Yee LD, Agarwal D, Rosol TJ, Lehman A, Tian M, Hatton J, Heestand J, Belury MA, Clinton SKThe inhibition of early stages of HER-2/neu-mediated mammary carcinogenesis by dietary n-3 PUFAs.Mol Nutr Food Res 57(2) 320-7 2/1/2013
  • Rosol TJOn-target effects of GLP-1 receptor agonists on thyroid C-cells in rats and mice.Toxicol Pathol 41(2) 303-9 2/1/2013
  • Keller JM, Schade GR, Ives K, Cheng X, Rosol TJ, Piert M, Siddiqui J, Roberts WW, Keller ETA novel canine model for prostate cancer.Prostate in press 1/17/2013
  • Schade GR, Keller J, Ives K, Cheng X, Rosol TJ, Keller E, Roberts WWHistotripsy focal ablation of implanted prostate tumor in an ACE-1 canine cancer model.J Urol 188(5) 1957-64 11/1/2012
  • Martin CK, Dirksen WP, Shu ST, Werbeck JL, Thudi NK, Yamaguchi M, Wolfe TD, Heller KN, Rosol TJCharacterization of bone resorption in novel in vitro and in vivo models of oral squamous cell carcinoma.Oral Oncol 48(6) 491-9 6/1/2012
  • Wise-Milestone L, Akens MK, Rosol TJ, Hojjat SP, Grynpas MD, Whyne CMEvaluating the effects of mixed osteolytic/osteoblastic metastasis on vertebral bone quality in a new rat model.J Orthop Res 30(5) 817-23 5/1/2012
  • Shu ST, Dirksen WP, Lanigan LG, Martin CK, Thudi NK, Werbeck JL, Fernandez SA, Hildreth BE, Rosol TJEffects of parathyroid hormone-related protein and macrophage inflammatory protein-1α in Jurkat T-cells on tumor formation in vivo and expression of apoptosis regulatory genes in vitro.Leuk Lymphoma 53(4) 688-98 4/1/2012
  • Berman-Booty LD, Sargeant AM, Rosol TJ, Rengel RC, Clinton SK, Chen CS, Kulp SKA review of the existing grading schemes and a proposal for a modified grading scheme for prostatic lesions in TRAMP mice.Toxicol Pathol 40(1) 5-17 1/1/2012
  • Thudi NK, Shu ST, Martin CK, Lanigan LG, Nadella MV, Van Bokhoven A, Werbeck JL, Simmons JK, Murahari S, Kisseberth WC, Breen M, Williams C, Chen CS, McCauley LK, Keller ET, Rosol TJDevelopment of a brain metastatic canine prostate cancer cell line.Prostate 71(12) 1251-63 9/1/2011