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Qianben Wang PhD

Qianben Wang PhD
Asst ProfessorCollege of Medicineqianben.wang@osumc.edu
888 BRT 460 W 12th Avenue Columbus OH 43210
Phone:614-247-1609Fax:
  • Molecular Carcinogenesis and Chemoprevention

General Research Interest

Nuclear receptor signaling in prostate and breast cancer

Research Description

My laboratory is interested in understanding the role of androgen receptor (AR) in the development and progression of prostate cancer. AR is a ligand-dependent transcription factor belonging to the nuclear hormone receptor (NR) superfamily. The application of chromatin immunoprecipitation (ChIP) to study protein-DNA interaction has provided a wealth of information on temporal and spatial assembly of AR transcription complex on target gene regulatory regions in vivo. However, studying of only a few target genes by ChIP greatly limits our understanding of how AR regulates target gene network. The recent development of the ChIP-on-chip (ChIP on a microarray) or ChIP-seq (ChIP combined with high throughput sequencing) technique allows the global identification of specific transcription factor regulatory regions across the human genome. Recently, we have mapped AR binding regions in the entire human genome in both androgen-dependent prostate cancer (ADPC) and androgen-independent prostate cancer (AIPC). By combining the AR binding maps with gene expression profiles, we have begun to understand how AR regulates target gene networks in ADPC and AIPC. Currently, we are extending our view from transcriptional regulation by AR to wider transcriptional regulations in prostate cancer including studying combinatorial transcriptional regulation by AR, its collaborating transcription factors, and its coactivators. We will also apply the genome-wide ChIP technique to clinical samples obtained from different stages of prostate cancer. This would allow identification of critical cis-regulatory sequences contributing to prostate cancer progression.

Transinstitutional Work

My Bioinformatics collaborator is Dr. Wei Li ( Assistant Professor, Division of Biostatistics, Dan L. Duncan Cancer Center, Baylor College of Medicine) who is a leader in sequence and microarray data analysis. We are currently collaborate on a NCI funded R00 project “ Genome-wide analysis of transcription factor function in prostate cancer”.The overall goal of this project is to improve our understanding of the combinatorial transcriptional regulation of target genes by AR, its collaborating transcription factors and its coactivators from a genome-wide view in ADPC and AIPC

Current Publications

  • He H, Li W, Wu D, Nagy R, Liyanarachchi S, Akagi K, Jendrzejewski J, Jiao H, Hoag K, Wen B, Srinivas M, Waidyaratne G, Wang R, Wojcicka A, Lattimer IR, Stachlewska E, Czetwertynska M, Dlugosinska J, Gierlikowski W, Ploski R, Krawczyk M, Jazdzewski K, Kere J, Symer DE, Jin V, Wang Q, de la Chapelle AUltra-rare mutation in long-range enhancer predisposes to thyroid carcinoma with high penetrance.PLoS One 8(5) e61920 1/1/2013
  • Taslim C, Chen Z, Huang K, Huang TH, Wang Q, Lin SIntegrated analysis identifies a class of androgen-responsive genes regulated by short combinatorial long-range mechanism facilitated by CTCF.Nucleic Acids Res 40(11) 4754-64 6/1/2012
  • Taslim C, Chen Z, Huang K, Huang TH, Wang Q, Lin SIntegrated analysis identifies a class of androgen-responsive genes regulated by short combinatorial long-range mechanism facilitated by CTCF.Nucleic Acids Res 40(11) 4754-64 6/1/2012
  • Zhao JC, Yu J, Runkle C, Wu L, Hu M, Wu D, Liu JS, Wang Q, Qin ZS, Yu JCooperation between Polycomb and androgen receptor during oncogenic transformation.Genome Res 22(2) 322-31 2/1/2012
  • Wu D, Zhang C, Shen Y, Nephew KP, Wang QAndrogen receptor-driven chromatin looping in prostate cancer.Trends Endocrinol Metab 22(12) 474-80 12/1/2011
  • Zhang C, Wang L, Wu D, Chen H, Chen Z, Thomas-Ahner J, Zynger D, Eeckhoute J, Yu J, Luo J, Brown M, Clinton SK, Nephew KP, Huang TH, Li W, Wang QDefinition of a FoxA1 Cistrome that is crucial for G1 to S-phase cell-cycle transit in castration-resistant prostate cancer.Cancer Res 71(21) 6738-48 11/1/2011
  • Zhang C, Wang L, Wu D, Chen H, Chen Z, Thomas-Ahner JM, Zynger DL, Eeckhoute J, Yu J, Luo J, Brown M, Clinton SK, Nephew KP, Huang TH, Li W, Wang QDefinition of a FoxA1 Cistrome that is crucial for G1 to S-phase cell-cycle transit in castration-resistant prostate cancer.Cancer Res 71(21) 6738-48 11/1/2011