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Thomas J Knobloch MS, PhD

Thomas J Knobloch MS, PhD
Research ScientistCollege of Public Healthtknobloch@cph.osu.edu
3160B Graves Hall 333 W 10th Avenue Columbus OH 43210
Phone:614-292-4168Fax: 614-293-7710
  • Molecular Carcinogenesis and Chemoprevention

General Research Interest

Mechanisms of molecular carcinogenesis and food-based cancer risk reduction strategies following a “Bench to Bedside,” “Crops to Clinics,” and “Farm to Pharma” philosophy.

Research Description

Molecular Carcinogenesis of the Tumor Microenvironment: Systematic evaluation of food-based cancer prevention in preclinical models (in vitro, in vivo) of oral carcinogenesis, and the translation of fundamental basic science discoveries into PhaseI/II human clinical trials. These studies provide essential biomarker and mechanism-of-action outcomes. Bioinformatics and High-Throughput Gene Expression Systems: Integration of basic science discovery data sets into medical bioinformatic pipelines to facilitate biomarker and mechanistic gene-of-action target discovery in oral and cervical cancers. Validation of discovery data sets by incorporation of “knowledge-based” informatics into “number-based” biostatistics to rationally model cellular responses in cancerous and high at-risk tissues.

Current Publications

  • Li J, Knobloch TJ, Poi MJ, Zhang Z, Davis AT, Muscarella P, Weghorst CMGenetic alterations of RD(INK4/ARF) enhancer in human cancer cells.Mol Carcinog in press 10/12/2012
  • Pereira MA, Warner BM, Knobloch TJ, Weghorst CM, Lubet RA, Steele VE, Casto BCChemoprevention of mouse lung and colon tumors by suberoylanilide hydroxamic acid and atorvastatin.Int J Cancer 131(6) 1277-86 9/15/2012
  • Zhang Z, Knobloch TJ, Seamon LG, Stoner GD, Cohn DE, Paskett ED, Fowler JM, Weghorst CMA black raspberry extract inhibits proliferation and regulates apoptosis in cervical cancer cells.Gynecol Oncol 123(2) 401-6 11/1/2011
  • Accurso BT, Warner BM, Knobloch TJ, Weghorst CM, Shumway BS, Allen CM, Kalmar JRAllelic imbalance in oral lichen planus and assessment of its classification as a premalignant condition.Oral Surg Oral Med Oral Pathol Oral Radiol Endod 112(3) 359-66 9/1/2011
  • Li J, Knobloch TJ, Kresty LA, Zhang Z, Lang JC, Schuller DE, Weghorst CMGankyrin, a biomarker for epithelial carcinogenesis, is overexpressed in human oral cancer.Anticancer Res 31(9) 2683-92 9/1/2011