Qi-En Wang PhD

Asst ProfessorCollege of MedicineQi-En.Wang@osumc.edu

718 BRT 460 W 12th Avenue Columbus OH 43210

Phone:614-292-9114Fax:

Molecular Carcinogenesis and Chemoprevention

General Research Interest

DNA repair, chromatin remodeling, cancer therapy resistance.

Research Description

The focus of my research is on the regulation of nucleotide excision repair (NER), one of the DNA repair pathways, and the connection of DNA repair to cancer therapy. My research strives to explore the mechanism of NER, and finally find means to prevent cancer initiation via improving normal cells’ capability to repair DNA damage or to enhance the efficacy of cancer therapy through inhibiting the repair of DNA damage induced by chemotherapeutic agents and radiotherapy. Three separate projects are being pursued: Chromatin modification and remodeling in NER following UV or cisplatin treatment; Protein posttranslational modifications and degradation in DNA repair; and Role of NER proteins in chemotherapeutic agents-induced apoptosis.

Current Publications

Yu J, Peng Y, Wu LC, Xie Z, Deng Y, Hughes T, He S, Mo X, Chiu M, Wang QE, He X, Liu S, Grever MR, Chan KK, Liu ZCurcumin down-regulates DNA methyltransferase 1 and plays an anti-leukemic role in acute myeloid leukemia.PLoS One 8(2) e55934 1/1/2013