Dehua Pei PhD

Dehua Pei PhD
ProfessorCollege of Arts and Sciencespei.3@osu.edu
100B Johnston Laboratory 176 W 19th Avenue Columbus Ohio 43210
Phone:614-688-4068Alternate Phone:(614) 292-3303Fax: (614) 292-1532
  • Molecular Carcinogenesis and Chemoprevention

General Research Interest

Chemical Biology/Combinatorial Chemistry/Organic Synthesis

Research Description

Dr. Pei's interest is in a variety of problems at the interface of chemistry and biology. A major area is to determine the molecular basis of biological processes by chemical methods. Dr. Pei is especially interested in identifying the interaction partners of protein modular domains and the in vivo substrates of protein tyrosine phosphatases. Another area is to develop new methodology for the synthesis, screening, and identification of cyclic peptides and peptidomimetics for biological activities and as organocatalysts. A third area is to determine the catalytic mechanisms of enzymes and to design inhibitors as research tools and potential therapeutic agents.

Transinstitutional Work

We are collaborating with Dr. Chuck Bell's lab (Mol. Cell. Biochem.) to study the structural basis of protein-protein inetractions. We have worked with Drs. Chuck Brooks and Jim DeWille (College of Vet. Science) to examine the effect of our synthetic compounds on cellular processes. We are also collaborating with Dr. Benjamin Neel of University of Toronto to determine the protein substrates of protein tyrosine phosphatases.

Current Publications

  • Upadhyaya P, Qian Z, Habir NA, Pei DDirect Ras Inhibitors Identified from a Structurally Rigidified Bicyclic Peptide Library.Tetrahedron 70 7714-7720 10/21/2014
  • Qian Z, Dougherty PG, Liu T, Oottikkal S, Hogan PG, Hadad CM, Pei DStructure-Based Optimization of a Peptidyl Inhibitor against Calcineurin-Nuclear Factor of Activated T Cell (NFAT) Interaction.J Med Chem in press 9/4/2014
  • Selner NG, Luechapanichkul R, Chen X, Neel BG, Zhang ZY, Knapp S, Bell CE, Pei DDiverse levels of sequence selectivity and catalytic efficiency of protein-tyrosine phosphatases.Biochemistry 53 397-412 1/21/2014
  • Trinh TB, Xiao Q, Pei DProfiling the substrate specificity of protein kinases by on-bead screening of peptide libraries.Biochemistry 52 5645-55 8/20/2013
  • Lian W, Upadhyaya P, Rhodes CA, Liu Y, Pei DScreening bicyclic peptide libraries for protein-protein interaction inhibitors: discovery of a tumor necrosis factor-α antagonist.J Am Chem Soc 135 11990-5 8/14/2013
  • Xiao Q, Luechapanichkul R, Zhai Y, Pei DSpecificity profiling of protein phosphatases toward phosphoseryl and phosphothreonyl peptides.J Am Chem Soc 135 9760-7 7/3/2013
  • Zhao B, Tan PH, Li SS, Pei DSystematic characterization of the specificity of the SH2 domains of cytoplasmic tyrosine kinases.J Proteomics 81 56-69 4/9/2013
  • Luechapanichkul R, Chen X, Taha HA, Vyas S, Guan X, Freitas MA, Hadad CM, Pei DSpecificity profiling of dual specificity phosphatase vaccinia VH1-related (VHR) reveals two distinct substrate binding modes.J Biol Chem 288 6498-510 3/1/2013
  • Qian Z, Liu T, Liu YY, Briesewitz R, Barrios AM, Jhiang SM, Pei DEfficient delivery of cyclic peptides into mammalian cells with short sequence motifs.ACS Chem Biol 8 423-31 2/15/2013
  • Thakkar A, Trinh TB, Pei DGlobal analysis of peptide cyclization efficiency.ACS Comb Sci 15 120-9 2/11/2013
  • Wu X, Upadhyaya P, Villalona-Calero MA, Briesewitz R, Pei DInhibition of Ras-Effector Interaction by Cyclic Peptides.Medchemcomm 4 378-382 2/1/2013

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu