General Research InterestChemical Biology/Combinatorial Chemistry/Organic Synthesis
Research DescriptionWe are interested in a variety of problems at the interface of chemistry and biology. A major area is to determine the molecular basis of biological processes by chemical methods. We are especially interested in identifying the interaction partners of protein modular domains and the in vivo substrates of protein tyrosine phosphatases. Another area is to develop new methodology for the synthesis, screening, and identification of cyclic peptides and peptidomimetics for biological activities and as organocatalysts. A third area is to determine the catalytic mechanisms of enzymes and to design inhibitors as research tools and potential therapeutic agents.
Transinstitutional WorkWe are collaborating with Dr. Chuck Bell's lab (Mol. Cell. Biochem.) to study the structural basis of protein-protein inetractions. We have worked with Drs. Chuck Brooks and Jim DeWille (College of Vet. Science) to examine the effect of our synthetic compounds on cellular processes. We are also collaborating with Dr. Benjamin Neel of University of Toronto to determine the protein substrates of protein tyrosine phosphatases.