Dehua Pei PhD

Dehua Pei PhD
ProfessorArts and Sciencespei.3@osu.edu
100B Johnston Laboratory 176 W 19th Avenue Columbus Ohio 43210
Phone:614-688-4068Alternate Phone:614-292-3303Fax: 614-292-1532
  • Molecular Carcinogenesis and Chemoprevention

General Research Interest

Chemical Biology/Combinatorial Chemistry/Organic Synthesis

Research Description

We are interested in a variety of problems at the interface of chemistry and biology. A major area is to determine the molecular basis of biological processes by chemical methods. We are especially interested in identifying the interaction partners of protein modular domains and the in vivo substrates of protein tyrosine phosphatases. Another area is to develop new methodology for the synthesis, screening, and identification of cyclic peptides and peptidomimetics for biological activities and as organocatalysts. A third area is to determine the catalytic mechanisms of enzymes and to design inhibitors as research tools and potential therapeutic agents.

Transinstitutional Work

We are collaborating with Dr. Chuck Bell's lab (Mol. Cell. Biochem.) to study the structural basis of protein-protein inetractions. We have worked with Drs. Chuck Brooks and Jim DeWille (College of Vet. Science) to examine the effect of our synthetic compounds on cellular processes. We are also collaborating with Dr. Benjamin Neel of University of Toronto to determine the protein substrates of protein tyrosine phosphatases.

Current Publications

  • Lian W, Upadhyaya P, Rhodes CA, Liu Y, Pei DScreening bicyclic peptide libraries for protein-protein interaction inhibitors: discovery of a tumor necrosis factor-α antagonist.J Am Chem Soc 135(32) 11990-5 8/14/2013

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu