Thomas J Rosol DVM, PhD

Thomas J Rosol DVM, PhD
ProfessorCollege of Veterinary Medrosol.1@osu.edu
307 Goss Laboratory 1925 Coffey Road Columbus Ohio 43210
Phone:614-292-4265Fax: 614-292-6473
  • Molecular Carcinogenesis and Chemoprevention

Research Description

Thomas Rosol, DVM, PhD is a veterinary pathologist in the Department of Veterinary Biosciences. The Rosol Laboratory is NCI and NCRR-funded to develop mouse models of human cancer with emphasis on bone metastasis, bone resorption and formation, and cancer-associated hypercalcemia. The molecular regulation of parathyroid hormone-related protein (PTHrP) is studied in vitro and in vivo using animal models of prostate, lung, breast, and head & neck cancer, and lymphoma and PTHrP knockout mice. Both breast and prostate cancer metastasize to bone in humans, but breast cancer typically induces osteolytic disease and prostate cancer typically induces osteoblastic metastases. The Rosol laboratory has developed mouse models of breast and prostate cancer that mimic the metastases in humans and are used to investigate the pathogenesis and treatment of metastasis. Models of metastasis include intracardiac, intratibial, and orthotopic injections of tumor cells. Laboratory personnel include the PI, assistant professors, research scientist, post-professional PhD students, and undergraduate students. Laboratory expertise has been developed for in vivo imaging of cancer in mouse models using bioluminescence from luciferase-transduced cancer cells. The lab is also collaborating to examine the ability of nanoparticles to enhance the ultrasound imaging of cancer molecular markers. 

Current Publications

  • Berkman CEBiochemical characterization of prostate-specific membrane antigen from canine prostate carcinoma cells.Prostate 74 451-7 5/1/2014
  • Deng XAnticancer properties of Monascus metabolites.Anticancer Drugs 3/14/2014
  • Kniss DALoss of Myoferlin Redirects Breast Cancer Cell Motility towards Collective Migration.PLoS One 9 e86110 1/1/2014
  • Axiak-Bechtel SM, Kumar SR, Dank KK, Clarkson NA, Selting KA, Bryan JN, Rosol TJ, Espinosa J, Decedue CJNanoparticulate paclitaxel demonstrates antitumor activity in PC3 and Ace-1 aggressive prostate cancer cell lines.Invest New Drugs 31 1609-15 12/1/2013
  • Werbeck JL, Thudi NK, Martin CK, Premanandan C, Yu L, Ostrowksi MC, Rosol TJTumor Microenvironment Regulates Metastasis and Metastasis Genes of Mouse MMTV-PymT Mammary Cancer Cells In Vivo.Vet Pathol in press 10/3/2013
  • Wallace JA, Li F, Balakrishnan S, Cantemir-Stone CZ, Pecot T, Martin C, Kladney RD, Sharma SM, Trimboli AJ, Fernandez SA, Yu L, Rosol TJ, Stromberg PC, Lesurf R, Hallett M, Park M, Leone G, Ostrowski MCEts2 in tumor fibroblasts promotes angiogenesis in breast cancer.PLoS One 8(8) e71533 8/16/2013
  • Keller JM, Schade GR, Ives K, Cheng X, Rosol TJ, Piert M, Siddiqui J, Roberts WW, Keller ETA novel canine model for prostate cancer.Prostate 73(9) 952-9 6/1/2013
  • Martin CK, Dirksen WP, Carlton MM, Lanigan LG, Pillai SP, Werbeck JL, Simmons JK, Hildreth BE 3rd, London CA, Toribio RE, Rosol TJCombined zoledronic acid and meloxicam reduced bone loss and tumour growth in an orthotopic mouse model of bone-invasive oral squamous cell carcinoma.Vet Comp Oncol in press 5/8/2013
  • Sneh A, Deol YS, Ganju A, Shilo K, Rosol TJ, Nasser MW, Ganju RKDifferential role of psoriasin (S100A7) in estrogen receptor α positive and negative breast cancer cells occur through actin remodeling.Breast Cancer Res Treat 138(3) 727-39 4/1/2013
  • Yee LD, Agarwal D, Rosol TJ, Lehman A, Tian M, Hatton J, Heestand J, Belury MA, Clinton SKThe inhibition of early stages of HER-2/neu-mediated mammary carcinogenesis by dietary n-3 PUFAs.Mol Nutr Food Res 57(2) 320-7 2/1/2013
  • Rosol TJOn-target effects of GLP-1 receptor agonists on thyroid C-cells in rats and mice.Toxicol Pathol 41(2) 303-9 2/1/2013
  • Schade GR, Keller J, Ives K, Cheng X, Rosol TJ, Keller E, Roberts WWHistotripsy focal ablation of implanted prostate tumor in an ACE-1 canine cancer model.J Urol 188(5) 1957-64 11/1/2012
  • Martin CK, Dirksen WP, Shu ST, Werbeck JL, Thudi NK, Yamaguchi M, Wolfe TD, Heller KN, Rosol TJCharacterization of bone resorption in novel in vitro and in vivo models of oral squamous cell carcinoma.Oral Oncol 48(6) 491-9 6/1/2012

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu