Thomas Rosol J DVM, PhD

Thomas Rosol J DVM, PhD
ProfessorCollege of Veterinary Medrosol.1@osu.edu
307 Goss Laboratory 1925 Coffey Road Columbus Ohio 43210
Phone:614-292-4265Fax: (614) 292-6473
  • Molecular Carcinogenesis and Chemoprevention

Research Description

Dr. Rosol's Laboratory is NCI and NCRR-funded to develop mouse models of human cancer with emphasis on bone metastasis, bone resorption and formation, and cancer-associated hypercalcemia. The molecular regulation of parathyroid hormone-related protein (PTHrP) is studied in vitro and in vivo using animal models of prostate, lung, breast, and head & neck cancer, and lymphoma and PTHrP knockout mice. Both breast and prostate cancer metastasize to bone in humans, but breast cancer typically induces osteolytic disease and prostate cancer typically induces osteoblastic metastases. The Rosol lab has developed mouse models of breast and prostate cancer that mimic the metastases in humans and are used to investigate the pathogenesis and treatment of metastasis. Models of metastasis include intracardiac, intratibial, and orthotopic injections of tumor cells. The lab is also collaborating to examine the ability of nanoparticles to enhance the ultrasound imaging of cancer molecular markers. 

Current Publications

  • Simmons JK, Dirksen WP, Hildreth BE 3rd, Dorr C, Williams C, Thomas R, Breen M, Toribio RE, Rosol TJCanine prostate cancer cell line (Probasco) produces osteoblastic metastases in vivo.Prostate 74 1251-65 9/1/2014
  • Yang T, Liu J, Luo F, Lin Q, Rosol TJ, Deng XAnticancer properties of Monascus metabolites.Anticancer Drugs 25 735-44 8/1/2014
  • Harshman SW, Hoover ME, Huang C, Branson OE, Chaney SB, Cheney CM, Rosol TJ, Shapiro CL, Wysocki VH, Huebner K, Freitas MAHistone h1 phosphorylation in breast cancer.J Proteome Res 13 2453-67 5/2/2014
  • Wu LY, Johnson JM, Simmons JK, Mendes DE, Geruntho JJ, Liu T, Dirksen WP, Rosol TJ, Davis WC, Berkman CEBiochemical characterization of prostate-specific membrane antigen from canine prostate carcinoma cells.Prostate 74 451-7 5/1/2014
  • Wallace JA, Pitarresi JR, Sharma N, Palettas M, Sizemore ST, Yu L, Sanderlin A, Rosol TJ, Cuitiño MC, Mehta KD, Sizemore GM, Ostrowski MCProtein kinase C Beta in the tumor microenvironment promotes mammary tumorigenesis.Front Oncol 4 87 1/1/2014
  • Volakis LI, Li R, Ackerman WE 4th, Mihai C, Bechel M, Summerfield TL, Ahn CS, Powell HM, Zielinski R, Rosol TJ, Ghadiali SN, Kniss DALoss of myoferlin redirects breast cancer cell motility towards collective migration.PLoS One 9 e86110 1/1/2014
  • Axiak-Bechtel SM, Kumar SR, Dank KK, Clarkson NA, Selting KA, Bryan JN, Rosol TJ, Espinosa J, Decedue CJNanoparticulate paclitaxel demonstrates antitumor activity in PC3 and Ace-1 aggressive prostate cancer cell lines.Invest New Drugs 31 1609-15 12/1/2013
  • Martin CK, Premanandan C, Yu L, Ostrowksi MC, Rosol TJ, Werbeck JL, Thudi NKTumor Microenvironment Regulates Metastasis and Metastasis Genes of Mouse MMTV-PymT Mammary Cancer Cells In Vivo.Vet Pathol in press 868-881 10/3/2013
  • Keller JM, Schade GR, Ives K, Cheng X, Rosol TJ, Piert M, Siddiqui J, Roberts WW, Keller ETA novel canine model for prostate cancer.Prostate 73 952-9 6/1/2013
  • Martin CK, Dirksen WP, Carlton MM, Lanigan LG, Pillai SP, Werbeck JL, Simmons JK, Hildreth BE 3rd, London CA, Toribio RE, Rosol TJCombined zoledronic acid and meloxicam reduced bone loss and tumour growth in an orthotopic mouse model of bone-invasive oral squamous cell carcinoma.Vet Comp Oncol in press 5/8/2013
  • Sneh A, Deol YS, Ganju A, Shilo K, Rosol TJ, Nasser MW, Ganju RKDifferential role of psoriasin (S100A7) in estrogen receptor α positive and negative breast cancer cells occur through actin remodeling.Breast Cancer Res Treat 138 727-39 4/1/2013
  • Rosol TJOn-target effects of GLP-1 receptor agonists on thyroid C-cells in rats and mice.Toxicol Pathol 41 303-9 2/1/2013
  • Heestand J, Belury MA, Clinton SK, Yee LD, Agarwal D, Rosol TJ, Lehman A, Tian M, Hatton JThe inhibition of early stages of HER-2/neu-mediated mammary carcinogenesis by dietary n-3 PUFAs.Mol Nutr Food Res 57 320-7 2/1/2013
  • Everds NE, Snyder PW, Bailey KL, Bolon B, Creasy DM, Foley GL, Rosol TJ, Sellers TInterpreting stress responses during routine toxicity studies: a review of the biology, impact, and assessment.Toxicol Pathol 41 560-614 1/1/2013
  • Wallace JA, Li F, Balakrishnan S, Cantemir-Stone CZ, Pecot T, Martin C, Kladney RD, Sharma SM, Trimboli AJ, Fernandez SA, Yu L, Rosol TJ, Stromberg PC, Lesurf R, Hallett M, Park M, Leone G, Ostrowski MCEts2 in tumor fibroblasts promotes angiogenesis in breast cancer.PLoS One 8 e71533 1/1/2013
  • Gulati P, Fernandez SA, Rosol TJ, Luchin AI, Nadella MV, Thudi NK, Dirksen WPAU-rich elements in the 3'-UTR regulate the stability of the 141 amino acid isoform of parathyroid hormone-related protein mRNA.Mol Cell Endocrinol 364 105-12 11/25/2012
  • Schade GR, Keller J, Ives K, Cheng X, Rosol TJ, Keller E, Roberts WWHistotripsy focal ablation of implanted prostate tumor in an ACE-1 canine cancer model.J Urol 188 1957-64 11/1/2012

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu