Chandan Sen K. PhD

Chandan Sen K. PhD
ProfessorCollege of Medicinesen.16@osu.edu
513 Davis Heart & Lung Research Inst 473 W 12th Avenue Columbus Ohio 43210
Phone:614-247-7786Fax: (614) 247-7818
  • Molecular Carcinogenesis and Chemoprevention

Research Description

Dr. Sen’s program is interested in tissue injury and repair and works across three organ systems- skin, brain and heart. His group is interested in miRNA biology, redox signaling and tissue oxygenation. In the skin, the Sen group works on wound healing – both experimental as well as clinical. In the brain, specific focus is directed towards stroke biology and related neurodegeneration. The Sen group has identified the alpha-tocotrienol form of vitamin E as a major protector against stroke-induced injury to the brain. In the heart, emphasis is on post-infarction myocardial remodeling with emphasis on miRNA biology. Across all of the above programs, the Sen groups uses advanced MRI, echocardiographic as well hyperspectral imaging approaches.

Current Publications

  • Powell HM, Cook CH, Gordillo GM, Wozniak DJ, Sen CK, Roy S, Elgharably H, Sinha M, Ganesh K, Chaney S, Mann E, Miller C, Khanna S, Bergdall VKMixed-species biofilm compromises wound healing by disrupting epidermal barrier function.J Pathol 233 331-43 8/1/2014
  • Gordillo GM, Biswas A, Khanna S, Pan X, Sinha M, Roy S, Sen CKDicer knockdown inhibits endothelial cell tumor growth via microRNA 21a-3p targeting of Nox-4.J Biol Chem 289 9027-38 3/28/2014
  • Das A, Ganesh K, Khanna S, Sen CK, Roy SEngulfment of apoptotic cells by macrophages: a role of microRNA-21 in the resolution of wound inflammation.J Immunol 192 1120-9 2/1/2014
  • Liu B, Snyder JS, Lou Q, Brundage EA, Velez-Cortes F, Wang H, Ziolo MT, Anderson ME, Sen CK, Wehrens XH, Fedorov VV, Biesiadecki BJ, Hund TJ, Györke S, Ho HTRyanodine receptor phosphorylation by oxidized CaMKII contributes to the cardiotoxic effects of cardiac glycosides.Cardiovasc Res 101 165-74 1/1/2014
  • Banerjee J, Das Ghatak P, Roy S, Khanna S, Sequin EK, Bellman K, Dickinson BC, Suri P, Subramaniam VV, Chang CJ, Sen CKImprovement of human keratinocyte migration by a redox active bioelectric dressing.PLoS One 9 e89239 1/1/2014
  • Richmond NA, Lamel SA, Davidson JM, Martins-Green M, Sen CK, Tomic-Canic M, Vivas AC, Braun LR, Kirsner RSUS-National Institutes of Health-funded research for cutaneous wounds in 2012.Wound Repair Regen 21 789-92 11/1/2013
  • Wijesinghe DS, Chalfant CE, Chan YC, Banerjee J, Huang Y, Roy S, Sen CK, Khanna S, Rink C, Ghoorkhanian R, Gnyawali S, Heigel MLoss of miR-29b following acute ischemic stroke contributes to neural cell death and infarct size.J Cereb Blood Flow Metab 33 1197-206 8/1/2013
  • Elgharably H, Roy S, Khanna S, Abas M, Dasghatak P, Das A, Mohammed K, Sen CKA modified collagen gel enhances healing outcome in a preclinical swine model of excisional wounds.Wound Repair Regen 21 473-81 5/1/2013
  • Sen CKARS turns fifteen: la quinceañera bonita.Antioxid Redox Signal 18 1-4 1/1/2013
  • Banerjee J, Sen CKMicroRNAs in skin and wound healing.Methods Mol Biol 936 343-56 1/1/2013
  • Roy S, Banerjee J, Gnyawali SC, Khanna S, He G, Pfeiffer D, Zweier JL, Sen CKSuppression of Induced microRNA-15b Prevents Rapid Loss of Cardiac Function in a Dicer Depleted Model of Cardiac Dysfunction.PLoS One 8 e66789 1/1/2013
  • Awad H, Ganesh K, Ghatak PD, Gordillo G, Sai-Sudhakar CB, Roy S, Wozniak DJ, Sen CK, Elgharably H, Mann EFirst evidence of sternal wound biofilm following cardiac surgery.PLoS One 8 e70360 1/1/2013
  • Shapiro JP, Biswas S, Merchant AS, Satoskar A, Taslim C, Lin S, Rovin BH, Sen CK, Roy S, Freitas MAA quantitative proteomic workflow for characterization of frozen clinical biopsies: laser capture microdissection coupled with label-free mass spectrometry.J Proteomics 77 433-40 12/21/2012
  • Sen CK, Roy SOxymiRs in cutaneous development, wound repair and regeneration.Semin Cell Dev Biol 23 971-80 12/1/2012
  • Sen CK, Chan YC, Roy S, Huang Y, Khanna SThe microRNA miR-199a-5p down-regulation switches on wound angiogenesis by derepressing the v-ets erythroblastosis virus E26 oncogene homolog 1-matrix metalloproteinase-1 pathway.J Biol Chem 287 41032-43 11/30/2012

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu