Christopher M. Weghorst PhD

Christopher M. Weghorst PhD
ProfessorCollege of Public Healthweghorst.2@osu.edu
436 Cunz Hall 1841 Neil Avenue Columbus Ohio 43210
Phone:614-247-4942Fax: 614-293-7710
  • Molecular Carcinogenesis and Chemoprevention

General Research Interest

Molecular carcinogenesis and cancer chemoprevention of oral cancer.

Research Description

Dr. Weghorst and his research team are recognized nationally as a leader in the areas molecular and comparative carcinogenesis, focusing on the biological mechanisms, genetic susceptibility and chemoprevention of head and neck and cervical cancer development. His research program has three primary areas of research: i) genetic susceptibility of cancer, ii) food-based cancer prevention and iii) the translational assessment of prevention approaches in human clinical trials.

Current Publications

  • Li JAlterations in RDINK4/ARF -mediated en bloc regulation of the INK4-ARF locus in human squamous cell carcinoma of the head and neck.Mol Carcinog 12/2/2013
  • Yuan C, Guo Y, Zhu L, Guo W, Mahajan A, Weghorst CM, Li JThe Study of pH-Dependent Stability Shows that the TPLH-Mediated Hydrogen-Bonding Network Is Important for the Conformation and Stability of Human Gankyrin.Biochemistry in press 7/8/2013
  • Poi MJ, Knobloch TJ, Yuan C, Tsai MD, Weghorst CM, Li JEvidence that P12, a specific variant of P16(INK4A), plays a suppressive role in human pancreatic carcinogenesis.Biochem Biophys Res Commun 436(2) 217-22 6/28/2013
  • Li J, Knobloch TJ, Poi MJ, Zhang Z, Davis AT, Muscarella P, Weghorst CMGenetic alterations of RD(INK4/ARF) enhancer in human cancer cells.Mol Carcinog in press 10/12/2012
  • Pereira MA, Warner BM, Knobloch TJ, Weghorst CM, Lubet RA, Steele VE, Casto BCChemoprevention of mouse lung and colon tumors by suberoylanilide hydroxamic acid and atorvastatin.Int J Cancer 131(6) 1277-86 9/15/2012
  • Pereira MA, Warner BM, Knobloch TJ, Weghorst CM, Lubet RA, Steele VE, Casto BCChemoprevention of mouse lung and colon tumors by suberoylanilide hydroxamic acid and atorvastatin.Int J Cancer 131(6) 1277-86 9/15/2012

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu