Christopher Weghorst M PhD

Christopher Weghorst M PhD
ProfessorCollege of Public
436 Cunz Hall 1841 Neil Avenue Columbus Ohio 43210
Phone:614-247-4942Fax: (614) 293-7710
  • Molecular Carcinogenesis and Chemoprevention

General Research Interest

Molecular carcinogenesis and cancer chemoprevention of oral cancer.

Research Description

Dr. Weghorst and his research team are recognized nationally as a leader in the areas molecular and comparative carcinogenesis, focusing on the biological mechanisms, genetic susceptibility and chemoprevention of head and neck and cervical cancer development. His research program has three primary areas of research: i) genetic susceptibility of cancer, ii) food-based cancer prevention and iii) the translational assessment of prevention approaches in human clinical trials.

Current Publications

  • Warner BM, Casto BC, Knobloch TJ, Accurso BT, Weghorst CMChemoprevention of oral cancer by topical application of black raspberries on high at-risk mucosa.Oral Surg Oral Med Oral Pathol Oral Radiol 118 674-83 12/1/2014
  • Joehlin-Price AS, Elkins CT, Stephens JA, Cohn DE, Knobloch TJ, Weghorst CM, Suarez AAComprehensive evaluation of caspase-14 in vulvar neoplasia: An opportunity for treatment with black raspberry extract.Gynecol Oncol in press 9/22/2014
  • Mace TA, King SA, Ameen Z, Elnaggar O, Young G, Riedl KM, Schwartz SJ, Clinton SK, Knobloch TJ, Weghorst CM, Lesinski GBBioactive compounds or metabolites from black raspberries modulate T lymphocyte proliferation, myeloid cell differentiation and Jak/STAT signaling.Cancer Immunol Immunother 63 889-900 9/1/2014
  • Poi MJ, Knobloch TJ, Sears MT, Uhrig LK, Warner BM, Weghorst CM, Li JCoordinated Expression of Cyclin-dependent Kinase-4 and its Regulators in Human Oral Tumors.Anticancer Res 34 3285-92 7/1/2014
  • Li J, Knobloch TJ, Poi MJ, Zhang Z, Davis AT, Muscarella P, Weghorst CMGenetic alterations of RD(INK4/ARF) enhancer in human cancer cells.Mol Carcinog 53 211-8 3/1/2014
  • Poi MJ, Knobloch TJ, Sears MT, Warner BM, Uhrig LK, Weghorst CM, Li JAlterations in RD(INK4/ARF) -mediated en bloc regulation of the INK4-ARF locus in human squamous cell carcinoma of the head and neck.Mol Carcinog in press 12/2/2013
  • Weghorst CM, Guo Y, Pennell ML, Pearl DK, Knobloch TJ, Fernandez SThe choice of reference gene affects statistical efficiency in quantitative PCR data analysis.Biotechniques 55 207-9 10/1/2013
  • Yuan C, Guo Y, Zhu L, Guo W, Mahajan A, Weghorst CM, Li JThe study of pH-dependent stability shows that the TPLH-mediated hydrogen-bonding network is important for the conformation and stability of human gankyrin.Biochemistry 52 4848-57 7/16/2013
  • Poi MJ, Knobloch TJ, Yuan C, Tsai MD, Weghorst CM, Li JEvidence that P12, a specific variant of P16(INK4A), plays a suppressive role in human pancreatic carcinogenesis.Biochem Biophys Res Commun 436 217-22 6/28/2013

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 460 W. 10th Avenue, Columbus, OH 43210 Phone: 1-800-293-5066 | Email: