Pui-Kai Li PhD

Pui-Kai Li PhD
Assoc ProfessorCollege of Pharmacyli.27@osu.edu
338 Parks Hall 500 W 12th Avenue Columbus Ohio 43210
Phone:614-688-0253Fax: (614) 292-2435
  • Molecular Carcinogenesis and Chemoprevention

Research Description

The research area of Dr. Li focuses in the design, synthesis and biochemical testing of steroidal and non-steroidal steroid sulfatase inhibitors as potential agents for the treatment of hormone-dependent cancers.

Current Publications

  • Li Y, Buchsbaum DJ, Li PK, Roberts MJ, Arend RC, Samant RSMulti-targeted therapy of cancer by niclosamide: A new application for an old drug.Cancer Lett 349 8-14 7/10/2014
  • Netherby CS, Lindner I, Li PK, Gabrilovich DI, Abrams SI, Lee KP, Farren MR, Carlson LMTumor-induced STAT3 signaling in myeloid cells impairs dendritic cell generation by decreasing PKCβII abundance.Sci Signal 7 ra16 2/18/2014
  • Bhasin D, Etter JP, Chettiar SN, Mok M, Li PKAntiproliferative activities and SAR studies of substituted anthraquinones and 1,4-naphthoquinones.Bioorg Med Chem Lett 23 6864-7 12/15/2013
  • Pandit B, Hu Z, Chettiar SN, Zink J, Xiao Z, Etter JP, Bhasin D, Li PKStructure-activity relationship studies of thalidomide analogs with a taxol-like mode of action.Bioorg Med Chem Lett 23 6902-4 12/15/2013
  • Wu J, Umapathy G, Schönherr C, Ruuth K, Chand D, Witek B, Fuchs J, Li PK, Hugosson F, Daly RJ, Sattu K, Hochgräfe F, Palmer RH, Hallberg BPhosphoproteomic analysis of anaplastic lymphoma kinase (ALK) downstream signaling pathways identifies signal transducer and activator of transcription 3 as a functional target of activated ALK in neuroblastoma cells.FEBS J 280 5269-82 11/1/2013
  • Chettiar SN, Cooley JV, Park IH, Bhasin D, Chakravarti A, Li PK, Li C, Jacob NKDesign, synthesis and biological studies of survivin dimerization modulators that prolong mitotic cycle.Bioorg Med Chem Lett 23 5429-33 10/1/2013
  • Kroon P, Berry PA, Stower MJ, Rodrigues G, Mann VM, Simms M, Bhasin D, Chettiar S, Li C, Li PK, Maitland NJ, Collins ATJAK-STAT blockade inhibits tumor initiation and clonogenic recovery of prostate cancer stem-like cells.Cancer Res 73 5288-98 8/15/2013
  • Bhasin D, Chettiar SN, Etter JP, Mok M, Li PKAnticancer activity and SAR studies of substituted 1,4-naphthoquinones.Bioorg Med Chem 21 4662-9 8/1/2013
  • Sun Y, Pandit B, Chettiar SN, Etter JP, Lewis A, Johnsamuel J, Li PKDesign, synthesis and biological studies of novel tubulin inhibitors.Bioorg Med Chem Lett 23 4465-8 8/1/2013
  • Terzyan SS, Li PK, Hanigan MH, Wickham S, Regan N, West MB, Thai J, Cook PFInhibition of human γ-glutamyl transpeptidase: development of more potent, physiologically relevant, uncompetitive inhibitors.Biochem J 450 547-57 3/15/2013
  • Lin HJ, Sun D, Li PK, Li C, Korkaya H, Wicha MS, Lin J, Lin L, Hutzen B, Lee HF, Peng Z, Wang W, Zhao CEvaluation of STAT3 signaling in ALDH+ and ALDH+/CD44+/CD24- subpopulations of breast cancer cells.PLoS One 8 e82821 1/1/2013

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 460 W. 10th Avenue, Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu