Andrea I Doseff PhD

Andrea I Doseff PhD
Assoc ProfessorCollege of Medicinedoseff.1@osu.edu
201 Davis Heart & Lung Research Inst 473 W 12th Avenue Columbus Ohio 43210
Phone:614-292-9507Fax: 614-292-7778
  • Molecular Carcinogenesis and Chemoprevention

Research Description

Dr. Doseff's research explores various molecular and biochemical mechanisms that regulate cell death. Furthermore, her lab also concentrates on different signal transduction pathways that control apoptosis. They also study the role of pro and anti-apoptotic molecules during differentiation as well as identification of natural compounds and their mechanisms of action as potential anti-cancer and anti-inflammatory agents.

Current Publications

  • Lakshmanan A, Doseff AI, Ringel MD, Saji M, Rousset B, Zhang X, Jhiang SMApigenin in combination with Akt inhibition significantly enhances thyrotropin-stimulated radioiodide accumulation in thyroid cells.Thyroid 24 878-87 5/1/2014
  • Arango D, Morohashi K, Yilmaz A, Kuramochi K, Parihar A, Brahimaj B, Grotewold E, Doseff AIMolecular basis for the action of a dietary flavonoid revealed by the comprehensive identification of apigenin human targets.Proc Natl Acad Sci U S A 110 E2153-62 6/11/2013
  • Nahomi RB, Wang B, Raghavan CT, Voss O, Doseff AI, Santhoshkumar P, Nagaraj RHChaperone peptides of α-crystallin inhibit epithelial cell apoptosis, protein insolubilization, and opacification in experimental cataracts.J Biol Chem 288 13022-35 5/3/2013
  • Duarte S, Arango D, Parihar A, Hamel P, Yasmeen R, Doseff AIApigenin protects endothelial cells from lipopolysaccharide (LPS)-induced inflammation by decreasing caspase-3 activation and modulating mitochondrial function.Int J Mol Sci 14 17664-79 1/1/2013
  • Arango D, Parihar A, Villamena FA, Wang L, Freitas MA, Grotewold E, Doseff AIApigenin induces DNA damage through the PKCδ-dependent activation of ATM and H2AX causing down-regulation of genes involved in cell cycle control and DNA repair.Biochem Pharmacol 84 1571-80 12/15/2012
  • Das A, Gopalakrishnan B, Voss OH, Doseff AI, Villamena FAInhibition of ROS-induced apoptosis in endothelial cells by nitrone spin traps via induction of phase II enzymes and suppression of mitochondria-dependent pro-apoptotic signaling.Biochem Pharmacol 84 486-97 8/15/2012

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu