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Qishen Pang PhD

Qishen Pang PhD
Asst ProfessorCollege of Medicine--UCQishen.pang@cchmc.org
3333 Burnet Ave Cincinnati OH 45229
Phone:513-636-1152Fax: 513-636-3768
  • Molecular Carcinogenesis and Chemoprevention

General Research Interest

Genomic instability, Fanconi anemia, leukemia, nucleophosmin,oxidative stress

Research Description

We study how Fanconi anemia (FA) proteins function to prevent stress-induced apoptosis and clonal evolution of hematopoietic stem cells and progenitors. We also work on a project involving the mechanism by which nucleophosmin (NPM) promotes cell proliferation and suppresses apoptosis, and the role of NPM in the selection and progression of human cancers, particularly in the context of p53 regulation.

Transinstitutional Work

None at the moment.

Current Publications

  • Shen C, Oswald D, Phelps D, Cam H, Pelloski CE, Pang Q, Houghton PJRegulation of FANCD2 by the mTOR pathway contributes to the resistance of cancer cells to DNA double strand breaks.Cancer Res in press 4/30/2013
  • Mehta PA, Svahn J, Davies SM, Pang Q, Harris R, Ghezzi P, Lanza T, Ferretti E, Barabino P, Mueller R, Dufour CEtanercept treatment in Fanconi anaemia; combined US and Italian experience.Br J Haematol 158(6) 809-11 9/1/2012
  • Du W, Rani R, Sipple J, Schick J, Myers KC, Mehta P, Andreassen PR, Davies SM, Pang QThe FA pathway counteracts oxidative stress through selective protection of antioxidant defense gene promoters.Blood 119(18) 4142-51 5/3/2012