Qishen Pang PhD

Qishen Pang PhD
Asst ProfessorCollege of Medicine--UCQishen.pang@cchmc.org
3333 Burnet Ave Cincinnati OH 45229
Phone:513-636-1152Fax: 513-636-3768
  • Molecular Carcinogenesis and Chemoprevention

General Research Interest

Genomic instability, Fanconi anemia, leukemia, nucleophosmin,oxidative stress

Research Description

We study how Fanconi anemia (FA) proteins function to prevent stress-induced apoptosis and clonal evolution of hematopoietic stem cells and progenitors. We also work on a project involving the mechanism by which nucleophosmin (NPM) promotes cell proliferation and suppresses apoptosis, and the role of NPM in the selection and progression of human cancers, particularly in the context of p53 regulation.

Transinstitutional Work

None at the moment.

Current Publications

  • Pang QDeletion of Fanca or Fancd2 dysregulates Treg in mice.Blood 123 1938-47 3/20/2014
  • Du W, Amarachintha S, Sipple J, Schick J, Steinbrecher K, Pang QInflammation-mediated notch signaling skews fanconi anemia hematopoietic stem cell differentiation.J Immunol 191(5) 2806-17 9/1/2013
  • Guo F, Zhang S, Grogg M, Cancelas JA, Varney ME, Starczynowski DT, Du W, Yang JQ, Liu W, Zhu W, Thomas G, Kozma S, Pang Q, Zheng YMouse gene targeting reveals an essential role of mTOR in hematopoietic stem cell engraftment and hematopoiesis.Haematologica 98(9) 1353-8 9/1/2013
  • Du W, Erden O, Pang QTNF-α signaling in Fanconi anemia.Blood Cells Mol Dis in press 7/24/2013
  • Guo F, Li J, Zhang S, Du W, Amarachintha S, Sipple J, Phelan J, Grimes HL, Zheng Y, Pang QmTOR kinase inhibitor sensitizes T-cell lymphoblastic leukemia for chemotherapy-induced DNA damage via suppressing FANCD2 expression.Leukemia in press 7/15/2013
  • Shen C, Oswald D, Phelps D, Cam H, Pelloski CE, Pang Q, Houghton PJRegulation of FANCD2 by the mTOR pathway contributes to the resistance of cancer cells to DNA double-strand breaks.Cancer Res 73(11) 3393-401 6/1/2013
  • Mehta PA, Svahn J, Davies SM, Pang Q, Harris R, Ghezzi P, Lanza T, Ferretti E, Barabino P, Mueller R, Dufour CEtanercept treatment in Fanconi anaemia; combined US and Italian experience.Br J Haematol 158(6) 809-11 9/1/2012
  • Du W, Rani R, Sipple J, Schick J, Myers KC, Mehta P, Andreassen PR, Davies SM, Pang QThe FA pathway counteracts oxidative stress through selective protection of antioxidant defense gene promoters.Blood 119(18) 4142-51 5/3/2012

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu