Peter Muscarella MD

Peter Muscarella MD
Assoc ProfessorCollege of Medicinemuscarella.2@osu.edu
N711 Doan Hall 410 W 10th Avenue Columbus Ohio 43210
Phone:614-293-5815Fax: 614-293-4030
  • Molecular Carcinogenesis and Chemoprevention

General Research Interest

Pancreatic Cancer surgery and biology

Research Description

Pancreatic cancer is currently the fourth most common cancer causing death in the United States. The overall prognosis remains poor despite advances in diagnostic tests, surgical technique, multimodality treatment, and postoperative care. Dr. Muscarella participates in ongoing research focusing on pancreatic cancer genetics, novel therapies, surgical therapy, and the biological behavior of this disease.

Transinstitutional Work

Dr. Muscarella is currently the Principal Investigator of a multi-institutional trial evaluating the use of a novel vaccine targeting a frequently mutated protein (k-ras) in pancreatic cancers in the postoperative setting. Together with help from the clinical trials office and our team of pancreatic cancer surgeons and oncologists, we have entered more patients into this study than any other institution. Dr. Muscarella has also been collaborating with other surgeons and basic science researchers in the Division of Human Cancer Genetics in order to better understand the phenomenon of pancreatic cancer cachexia, or muscle wasting. This is a common clinical problem in patients with pancreatic cancer and it has profound effects on quality of life and patients’ abilities to tolerate necessary therapies. This work has resulted in publication in a respected scientific journal, as well as funding from the National Cancer Institute. Finally, Dr. Muscarella continues to work with other pancreatic surgeons in order to perform outcomes based research for patients undergoing pancreatic cancer surgery. A number of these studies have been published in scientific and surgical journals and/or presented at national scientific meetings. The pancreatic surgery team employs the use of cutting-edge technologies in the clinical care of patients such as minimally invasive pancreatectomy, natural orifice transluminal endoscopic surgery (NOTES), and en bloc portal vein resection with reconstruction for borderline-resectable pancreatic tumors. Much of this experience has been reported in the literature.

Current Publications

  • Poi MJ, Drosdeck J, Frankel WL, Muscarella P, Li JDeletions of RDINK4/ARF Enhancer in Gastrinomas and Nonfunctioning Pancreatic Neuroendocrine Tumors.Pancreas in press 7/7/2014
  • Perry KA, Kanji A, Drosdeck JM, Linn JG, Chan A, Muscarella P, Melvin WSEfficacy and durability of robotic heller myotomy for achalasia: patient symptoms and satisfaction at long-term follow-up.Surg Endosc in press 5/31/2014
  • Van Buren G, Bloomston M, Hughes SJ, Winter J, Behrman SW, Zyromski NJ, Vollmer C, Velanovich V, Riall T, Muscarella P, Trevino J, Nakeeb A, Schmidt CM, Behrns K, Ellison EC, Barakat O, Perry KA, Drebin J, House M, Abdel-Misih S, Silberfein EJ, Goldin S, Brown K, Mohammed S, Hodges SE, McElhany A, Issazadeh M, Jo E, Mo Q, Fisher WEA randomized prospective multicenter trial of pancreaticoduodenectomy with and without routine intraperitoneal drainage.Ann Surg 259 605-12 4/1/2014
  • Collins A, Hatzaras I, Schmidt C, Carruthers K, Melvin WS, Muscarella P, Ellison EC, Martin E, Bloomston MGastrectomy in advanced gastric cancer effectively palliates symptoms and may improve survival in select patients.J Gastrointest Surg 18 491-6 3/1/2014
  • Li J, Knobloch TJ, Poi MJ, Zhang Z, Davis AT, Muscarella P, Weghorst CMGenetic alterations of RD(INK4/ARF) enhancer in human cancer cells.Mol Carcinog 53 211-8 3/1/2014
  • Martin LK, Luu DC, Li X, Muscarella P, Ellison EC, Bloomston M, Bekaii-Saab TThe addition of radiation to chemotherapy does not improve outcome when compared to chemotherapy in the treatment of resected pancreas cancer: the results of a single-institution experience.Ann Surg Oncol 21 862-7 3/1/2014
  • He WA, Berardi E, Cardillo VM, Acharyya S, Aulino P, Thomas-Ahner J, Wang J, Bloomston M, Muscarella P, Nau P, Shah N, Butchbach ME, Ladner K, Adamo S, Rudnicki MA, Keller C, Coletti D, Montanaro F, Guttridge DCNF-κB-mediated Pax7 dysregulation in the muscle microenvironment promotes cancer cachexia.J Clin Invest 123 4821-35 11/1/2013
  • Perry KA, Funk LM, Muscarella P, Melvin WSPerioperative outcomes of laparoscopic transhiatal esophagectomy with antegrade esophageal inversion for high-grade dysplasia and invasive esophageal cancer.Surgery 154 901-7; discussion 907-8 10/1/2013
  • Drosdeck J, Carraro E, Arnold M, Perry K, Harzman A, Nagel R, Sinclair L, Muscarella PPorcine wet lab improves surgical skills in third year medical students.J Surg Res 184 19-25 9/1/2013
  • Rath KS, Loseth D, Muscarella P, Phillips GS, Fowler JM, O'Malley DM, Cohn DE, Copeland LJ, Eisenhauer EL, Salani ROutcomes following percutaneous upper gastrointestinal decompressive tube placement for malignant bowel obstruction in ovarian cancer.Gynecol Oncol 129 103-6 4/1/2013

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu