General Research InterestRole of dietary fat quality in modulating macronutrient metabolism; obesity, type diabetes, metabolic syndrome and cancer cachexia
Research DescriptionWe are interested in the study of whole body energy metabolism as regulated by interactions between adipose and muscle tissues. Canonical mechanisms of energy metabolism involve insulin-dependent and –independent pathways in each of these tissues. In addition, adipose secretes adipokines that regulate metabolism and inflammation in non-adipose tissues. We seek to understand how the availability or lack of availability of energy substrates and bioactive compounds (e.g., adipokines and dietary components) modulate metabolism and tissue function of adipose and muscle. Energy deprivation induces atrophy of muscle and adipose using some overlapping mechanisms including altered metabolism, inflammation, proteolysis and cell death-associated signals. Our work with muscle involves identifying the steps of atrophy related to insulin-resistance, proteolysis and cell death. We use a murine model of muscle atrophy that is induced by cancer cachexia. In this mouse model, cachexia appears to involve early alterations of insulin-mediated metabolism and inflammation that contribute to diminished energy substrate and compromised function of skeletal muscle.
Transinstitutional WorkCancer center, Davis Heart and Lung Institute, OSUMC, CRC-CTSA