Martha Belury PhD

Martha Belury PhD
ProfessorColl of Education & Human Ecolbelury.1@osu.edu
302 Campbell Hall 1787 Neil Avenue Columbus Ohio 43210
Phone:614-292-1680Fax:
  • Molecular Carcinogenesis and Chemoprevention

General Research Interest

Role of dietary fat quality in modulating macronutrient metabolism; obesity, type diabetes, metabolic syndrome and cancer cachexia

Research Description

We are interested in the study of whole body energy metabolism as regulated by interactions between adipose and muscle tissues.   Canonical mechanisms of energy metabolism involve insulin-dependent and –independent pathways in each of these tissues. In addition, adipose secretes adipokines that regulate metabolism and inflammation in non-adipose tissues. We seek to understand how the availability or lack of availability of energy substrates and bioactive compounds (e.g.,  adipokines and dietary components) modulate metabolism and tissue function of adipose and muscle. Energy deprivation induces atrophy of muscle and adipose using some overlapping mechanisms including altered metabolism, inflammation, proteolysis and cell death-associated signals.  Our work with muscle involves identifying the steps of atrophy related to insulin-resistance, proteolysis and cell death.  We use a murine model of muscle atrophy that is induced by cancer cachexia. In this mouse model, cachexia appears to involve early alterations of insulin-mediated metabolism and inflammation that contribute to diminished energy substrate and compromised function of skeletal muscle.

Transinstitutional Work

Cancer center, Davis Heart and Lung Institute, OSUMC, CRC-CTSA

Current Publications

  • Kiecolt-Glaser JK, Epel ES, Belury M, Andridge R, Lin J, Glaser R, Malarkey WB, Hwang BS, Blackburn EOmega-3 fatty acids, oxidative stress, and leukocyte telomere length: A randomized controlled trial.Brain Behav Immun 28 16-24 2/1/2013
  • Yee LD, Agarwal D, Rosol TJ, Lehman A, Tian M, Hatton J, Heestand J, Belury MA, Clinton SKThe inhibition of early stages of HER-2/neu-mediated mammary carcinogenesis by dietary n-3 PUFAs.Mol Nutr Food Res 57(2) 320-7 2/1/2013
  • Kiecolt-Glaser JK, Christian LM, Andridge R, Hwang BS, Malarkey WB, Belury M, Emery CF, Glaser MAdiponectin, leptin, and yoga practice.Physiol Behav 107(5) 809-13 12/5/2012
  • Kiecolt-Glaser JK, Belury MA, Andridge R, Malarkey WB, Hwang BS, Glaser ROmega-3 supplementation lowers inflammation in healthy middle-aged and older adults: a randomized controlled trial.Brain Behav Immun 26(6) 988-95 8/1/2012

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu