Traci A Wilgus PhD

Traci A Wilgus PhD
Asst ProfessorCollege of Medicinewilgus.3@osu.edu
M364B Starling Loving Hall 320 W 10th Avenue Columbus Ohio 43210
Phone:614-366-8526Fax: 614-366-9389
  • Molecular Carcinogenesis and Chemoprevention

General Research Interest

Our laboratory is interested in understanding how inflammation and angiogenesis contribute to non-melanoma skin cancer.

Research Description

Currently, we are studying the involvement of the pro-angiogenic growth factor vascular endothelial growth factor (VEGF) in skin carcinogenesis. VEGF is known to contribute to skin carcinogenesis by enhancing angiogenesis, but we believe that VEGF may also bind receptors in normal epithelial cells and tumor cells in the skin. We have found that VEGFR-1 (VEGF receptor-1) is expressed by normal epidermal keratinocytes and tumor cells from non-melanoma skin cancers. Studies are underway to determine whether VEGF can directly influence these cells by signaling through VEGFR-1, and the potential importance of epithelial VEGFR-1 signaling for the growth and development of skin tumors.

Current Publications

  • Johnson KE, Wulff BC, Oberyszyn TM, Wilgus TAUltraviolet light exposure stimulates HMGB1 release by keratinocytes.Arch Dermatol Res 305 805-15 11/1/2013

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu