Qianben Wang PhD

Qianben Wang PhD
Assoc ProfessorCollege of Medicinewang.1359@osu.edu
888 Biomedical Research Tower 460 W 12th Avenue Columbus Ohio 43210
  • Molecular Carcinogenesis and Chemoprevention

General Research Interest

Nuclear receptor signaling in prostate and breast cancer

Research Description

Dr. Wang's laboratory is interested in understanding the role of androgen receptor (AR) in the development and progression of prostate cancer. AR is a ligand-dependent transcription factor belonging to the nuclear hormone receptor (NR) superfamily. The application of chromatin immunoprecipitation (ChIP) to study protein-DNA interaction has provided a wealth of information on temporal and spatial assembly of AR transcription complex on target gene regulatory regions in vivo. However, studying of only a few target genes by ChIP greatly limits our understanding of how AR regulates target gene network. The recent development of the ChIP-on-chip (ChIP on a microarray) or ChIP-seq (ChIP combined with high throughput sequencing) technique allows the global identification of specific transcription factor regulatory regions across the human genome. They have mapped AR binding regions in the entire human genome in both androgen-dependent prostate cancer (ADPC) and androgen-independent prostate cancer (AIPC).

Transinstitutional Work

My Bioinformatics collaborator is Dr. Wei Li ( Assistant Professor, Division of Biostatistics, Dan L. Duncan Cancer Center, Baylor College of Medicine) who is a leader in sequence and microarray data analysis. We are currently collaborate on a NCI funded R00 project “ Genome-wide analysis of transcription factor function in prostate cancer”.The overall goal of this project is to improve our understanding of the combinatorial transcriptional regulation of target genes by AR, its collaborating transcription factors and its coactivators from a genome-wide view in ADPC and AIPC

Current Publications

  • Wu D, Sunkel B, Chen Z, Liu X, Ye Z, Li Q, Grenade C, Ke J, Zhang C, Chen H, Nephew KP, Huang TH, Liu Z, Jin VX, Wang QThree-tiered role of the pioneer factor GATA2 in promoting androgen-dependent gene expression in prostate cancer.Nucleic Acids Res 42 4/1/2014
  • Zhang M, Manchanda PK, Wu D, Wang Q, Kirschner LSKnockdown of PRKAR1A, the gene responsible for Carney complex, interferes with differentiation in osteoblastic cells.Mol Endocrinol 28 295-307 3/1/2014
  • Ye Z, Chen Z, Lan X, Hara S, Sunkel B, Huang TH, Elnitski L, Wang Q, Jin VXComputational analysis reveals a correlation of exon-skipping events with splicing, transcription and epigenetic factors.Nucleic Acids Res 42 2856-69 3/1/2014
  • Chen H, Ma J, Sunkel B, Luo A, Ding F, Li Y, He H, Zhang S, Xu C, Jin Q, Wang Q, Liu ZS100A14: novel modulator of terminal differentiation in esophageal cancer.Mol Cancer Res 11 1542-53 12/1/2013
  • Cai C, Wang H, He HH, Chen S, He L, Ma F, Mucci L, Wang Q, Fiore C, Sowalsky AG, Loda M, Liu XS, Brown M, Balk SP, Yuan XERG induces androgen receptor-mediated regulation of SOX9 in prostate cancer.J Clin Invest 123 1109-22 3/1/2013
  • Wojcicka A, Lattimer IR, Stachlewska E, Czetwertynska M, Dlugosinska J, Gierlikowski W, Ploski R, Krawczyk M, Jazdzewski K, Kere J, Symer DE, Jin V, Wang Q, de la Chapelle A, He H, Li W, Wu D, Nagy R, Liyanarachchi S, Akagi K, Jendrzejewski J, Jiao H, Hoag K, Wen B, Srinivas M, Waidyaratne G, Wang RUltra-rare mutation in long-range enhancer predisposes to thyroid carcinoma with high penetrance.PLoS One 8 e61920 1/1/2013

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 460 W. 10th Avenue, Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu