Earl Harrison H PhD

Earl Harrison H PhD
Dean's Distinguised ProfessorCollege of Education & Human Ecologyharrison.304@osu.edu
314 Campbell Hall 1787 Neil Avenue Columbus Ohio 43210
  • Molecular Carcinogenesis and Chemoprevention

Research Description

Dr. Harrison’s laboratory studies the basic mechanisms involved in the intestinal absorption, transport, and metabolism of dietary vitamin A and carotenoids using cell culture, animal models, and investigations in human subjects. He is particularly interested in defining the proteins involved in the uptake and metabolism of dietary carotenoids in the intestine.

Current Publications

  • Sun J, Narayanasamy S, Curley RW, Harrison EHβ-apo-13-Carotenone Regulates Retinoid X Receptor Transcriptional Activity Through Tetramerization of the Receptor.J Biol Chem in press 10/16/2014
  • Lee SA, Jiang H, Trent CM, Yuen JJ, Narayanasamy S, Curley RW Jr, Harrison EH, Goldberg IJ, Maurer MS, Blaner WSCardiac Dysfunction in β-Carotene-15,15'-Dioxygenase-Deficient Mice is Associated with Altered Retinoid and Lipid Metabolism.Am J Physiol Heart Circ Physiol in press 9/26/2014
  • Kopec RE, Cooperstone JL, Schweiggert RM, Young GS, Harrison EH, Francis DM, Clinton SK, Schwartz SJAvocado Consumption Enhances Human Postprandial Provitamin A Absorption and Conversion from a Novel High-β-Carotene Tomato Sauce and from Carrots.J Nutr 144 1158-66 8/1/2014
  • dela Seña C, Riedl KM, Narayanasamy S, Curley RW, Schwartz SJ, Harrison EHThe human enzyme that converts dietary provitamin A carotenoids to vitamin A is a dioxygenase.J Biol Chem 289 13661-6 5/9/2014
  • dela Seña C, Narayanasamy S, Riedl KM, Curley RW Jr, Schwartz SJ, Harrison EHSubstrate specificity of purified recombinant human β-carotene 15,15'-oxygenase (BCO1).J Biol Chem 288 37094-103 12/27/2013
  • Eroglu A, Harrison EHCarotenoid metabolism in mammals, including man: formation, occurrence, and function of apocarotenoids.J Lipid Res 54 1719-30 7/1/2013

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 460 W. 10th Avenue, Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu