Earl Harrison H PhD

Earl Harrison H PhD
Dean's Distinguised ProfessorColl of Education & Human Ecolharrison.304@osu.edu
314 Campbell Hall 1787 Neil Avenue Columbus Ohio 43210
Phone:614-292-8189Fax:
  • Molecular Carcinogenesis and Chemoprevention

Research Description

Dr. Harrison’s laboratory studies the basic mechanisms involved in the intestinal absorption, transport, and metabolism of dietary vitamin A and carotenoids using cell culture, animal models, and investigations in human subjects. He is particularly interested in defining the proteins involved in the uptake and metabolism of dietary carotenoids in the intestine.

Current Publications

  • Clinton SK, Schwartz SJ, Kopec RE, Cooperstone JL, Schweiggert RM, Young GS, Harrison EH, Francis DMAvocado Consumption Enhances Human Postprandial Provitamin A Absorption and Conversion from a Novel High-β-Carotene Tomato Sauce and from Carrots.J Nutr 144 1158-66 8/1/2014
  • dela Seña C, Riedl KM, Narayanasamy S, Curley RW, Schwartz SJ, Harrison EHThe human enzyme that converts dietary provitamin A carotenoids to vitamin A is a dioxygenase.J Biol Chem 289 13661-6 5/9/2014
  • dela Seña C, Narayanasamy S, Riedl KM, Curley RW, Schwartz SJ, Harrison EHSubstrate specificity of purified recombinant human β-carotene 15,15'-oxygenase (BCO1).J Biol Chem 288 37094-103 12/27/2013
  • Eroglu A, Harrison EHCarotenoid metabolism in mammals, including man: formation, occurrence, and function of apocarotenoids.J Lipid Res 54 1719-30 7/1/2013
  • Harrison EH, dela Sena C, Eroglu A, Fleshman MKThe formation, occurrence, and function of β-apocarotenoids: β-carotene metabolites that may modulate nuclear receptor signaling.Am J Clin Nutr 96 1189S-92S 11/1/2012

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu