Thomas J Knobloch MS, PhD

Thomas J Knobloch MS, PhD
Res ScientistCollege of Public Healthknobloch.1@osu.edu
434 Cunz Hall 1841 Neil Avenue Columbus Ohio 43210
Phone:614-292-4168Fax: 614-293-7710
  • Molecular Carcinogenesis and Chemoprevention

General Research Interest

Mechanisms of molecular carcinogenesis and food-based cancer risk reduction strategies following a “Bench to Bedside,” “Crops to Clinics,” and “Farm to Pharma” philosophy.

Research Description

Molecular Carcinogenesis of the Tumor Microenvironment: Systematic evaluation of food-based cancer prevention in preclinical models (in vitro, in vivo) of oral carcinogenesis, and the translation of fundamental basic science discoveries into PhaseI/II human clinical trials. These studies provide essential biomarker and mechanism-of-action outcomes. Bioinformatics and High-Throughput Gene Expression Systems: Integration of basic science discovery data sets into medical bioinformatic pipelines to facilitate biomarker and mechanistic gene-of-action target discovery in oral and cervical cancers. Validation of discovery data sets by incorporation of “knowledge-based” informatics into “number-based” biostatistics to rationally model cellular responses in cancerous and high at-risk tissues.

Current Publications

  • Li JAlterations in RDINK4/ARF -mediated en bloc regulation of the INK4-ARF locus in human squamous cell carcinoma of the head and neck.Mol Carcinog 12/2/2013
  • Casto BC, Knobloch TJ, Galioto RL, Yu Z, Accurso BT, Warner BMChemoprevention of oral cancer by lyophilized strawberries.Anticancer Res 33 4757-66 11/1/2013
  • Poi MJ, Knobloch TJ, Yuan C, Tsai MD, Weghorst CM, Li JEvidence that P12, a specific variant of P16(INK4A), plays a suppressive role in human pancreatic carcinogenesis.Biochem Biophys Res Commun 436(2) 217-22 6/28/2013
  • Li J, Knobloch TJ, Poi MJ, Zhang Z, Davis AT, Muscarella P, Weghorst CMGenetic alterations of RD(INK4/ARF) enhancer in human cancer cells.Mol Carcinog in press 10/12/2012
  • Pereira MA, Warner BM, Knobloch TJ, Weghorst CM, Lubet RA, Steele VE, Casto BCChemoprevention of mouse lung and colon tumors by suberoylanilide hydroxamic acid and atorvastatin.Int J Cancer 131(6) 1277-86 9/15/2012
  • Pereira MA, Warner BM, Knobloch TJ, Weghorst CM, Lubet RA, Steele VE, Casto BCChemoprevention of mouse lung and colon tumors by suberoylanilide hydroxamic acid and atorvastatin.Int J Cancer 131(6) 1277-86 9/15/2012

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu