Thomas Knobloch J MS, PhD

Thomas Knobloch J MS, PhD
Res ScientistCollege of Public Healthknobloch.1@osu.edu
434 Cunz Hall 1841 Neil Avenue Columbus Ohio 43210
Phone:614-292-4168Fax: (614) 293-7710
  • Molecular Carcinogenesis and Chemoprevention

General Research Interest

Mechanisms of molecular carcinogenesis and food-based cancer risk reduction strategies following a “Bench to Bedside,” “Crops to Clinics,” and “Farm to Pharma” philosophy.

Research Description

Dr. Knobloch's interests include the mechanisms of molecular carcinogenesis and their interaction with food-based cancer risk reduction strategies following a "Bench to Bedside," "Crop to Clinic," and "Farm to Pharma" philosophy. Dr. Knobloch's work currently emphasizes the role of black raspberry and strawberry phytochemicals and their associated bioactive derivatives and metabolites. His research efforts focus on defining translationally relevant molecular profiles that occur during the multistep process of oral carcinogenic progression in a manner that will advance the understanding of food-based intervention strategies for health promotion and disease prevention.

Current Publications

  • Warner BM, Casto BC, Knobloch TJ, Accurso BT, Weghorst CMChemoprevention of oral cancer by topical application of black raspberries on high at-risk mucosa.Oral Surg Oral Med Oral Pathol Oral Radiol 118 674-83 12/1/2014
  • Joehlin-Price AS, Elkins CT, Stephens JA, Cohn DE, Knobloch TJ, Weghorst CM, Suarez AAComprehensive evaluation of caspase-14 in vulvar neoplasia: An opportunity for treatment with black raspberry extract.Gynecol Oncol in press 9/22/2014
  • Mace TA, King SA, Ameen Z, Elnaggar O, Young G, Riedl KM, Schwartz SJ, Clinton SK, Knobloch TJ, Weghorst CM, Lesinski GBBioactive compounds or metabolites from black raspberries modulate T lymphocyte proliferation, myeloid cell differentiation and Jak/STAT signaling.Cancer Immunol Immunother 63 889-900 9/1/2014
  • Poi MJ, Knobloch TJ, Sears MT, Uhrig LK, Warner BM, Weghorst CM, Li JCoordinated Expression of Cyclin-dependent Kinase-4 and its Regulators in Human Oral Tumors.Anticancer Res 34 3285-92 7/1/2014
  • Li J, Knobloch TJ, Poi MJ, Zhang Z, Davis AT, Muscarella P, Weghorst CMGenetic alterations of RD(INK4/ARF) enhancer in human cancer cells.Mol Carcinog 53 211-8 3/1/2014
  • Poi MJ, Knobloch TJ, Sears MT, Warner BM, Uhrig LK, Weghorst CM, Li JAlterations in RD(INK4/ARF) -mediated en bloc regulation of the INK4-ARF locus in human squamous cell carcinoma of the head and neck.Mol Carcinog in press 12/2/2013
  • Casto BC, Knobloch TJ, Galioto RL, Yu Z, Accurso BT, Warner BMChemoprevention of oral cancer by lyophilized strawberries.Anticancer Res 33 4757-66 11/1/2013
  • Weghorst CM, Guo Y, Pennell ML, Pearl DK, Knobloch TJ, Fernandez SThe choice of reference gene affects statistical efficiency in quantitative PCR data analysis.Biotechniques 55 207-9 10/1/2013
  • Poi MJ, Knobloch TJ, Yuan C, Tsai MD, Weghorst CM, Li JEvidence that P12, a specific variant of P16(INK4A), plays a suppressive role in human pancreatic carcinogenesis.Biochem Biophys Res Commun 436 217-22 6/28/2013

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 460 W. 10th Avenue, Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu