Qi-En Wang PhD

Qi-En Wang PhD
Asst ProfessorCollege of Medicinewang.771@osu.edu
736 Biomedical Research Tower 460 W 12th Avenue Columbus Ohio 43210
  • Molecular Carcinogenesis and Chemoprevention

General Research Interest

DNA repair, chromatin remodeling, cancer therapy resistance.

Research Description

The focus of my research is on the regulation of nucleotide excision repair (NER), one of the DNA repair pathways, and the connection of DNA repair to cancer therapy. My research strives to explore the mechanism of NER, and finally find means to prevent cancer initiation via improving normal cells’ capability to repair DNA damage or to enhance the efficacy of cancer therapy through inhibiting the repair of DNA damage induced by chemotherapeutic agents and radiotherapy. Three separate projects are being pursued: Chromatin modification and remodeling in NER following UV or cisplatin treatment; Protein posttranslational modifications and degradation in DNA repair; and Role of NER proteins in chemotherapeutic agents-induced apoptosis.

Current Publications

  • Yu JGenetic Modification of T Cells Redirected towards CS1 Enhances Eradication of Myeloma Cells.Clin Cancer Res 3/27/2014
  • Wang QEDNA Damage-Binding Complex Recruits HDAC1 to Repress Bcl-2 Transcription in Human Ovarian Cancer Cells.Mol Cancer Res 12 370-80 3/1/2014
  • Wang QEDDB2 Suppresses Tumorigenicity by Limiting the Cancer Stem Cell Population in Ovarian Cancer.Mol Cancer Res 2/26/2014
  • Yu J, Peng Y, Wu LC, Xie Z, Deng Y, Hughes T, He S, Mo X, Chiu M, Wang QE, He X, Liu S, Grever MR, Chan KK, Liu ZCurcumin down-regulates DNA methyltransferase 1 and plays an anti-leukemic role in acute myeloid leukemia.PLoS One 8(2) e55934 1/1/2013

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu