Qi-En Wang PhD

Qi-En Wang PhD
Asst ProfessorCollege of Medicinewang.771@osu.edu
736 Biomedical Research Tower 460 W 12th Avenue Columbus Ohio 43210
  • Molecular Carcinogenesis and Chemoprevention

General Research Interest

DNA repair, chromatin remodeling, cancer therapy resistance.

Research Description

The focus of Dr. Wang's research is on the regulation of nucleotide excision repair (NER), one of the DNA repair pathways, and the connection of DNA repair to cancer therapy. Dr. Wang's research strives to explore the mechanism of NER, and finally find means to prevent cancer initiation via improving normal cells’ capability to repair DNA damage or to enhance the efficacy of cancer therapy through inhibiting the repair of DNA damage induced by chemotherapeutic agents and radiotherapy. Three separate projects are being pursued: Chromatin modification and remodeling in NER following UV or cisplatin treatment; Protein posttranslational modifications and degradation in DNA repair; and Role of NER proteins in chemotherapeutic agents-induced apoptosis.

Current Publications

  • Chu J, He S, Deng Y, Zhang J, Peng Y, Hughes T, Yi L, Kwon CH, Wang QE, Devine SM, He X, Bai XF, Hofmeister CC, Yu JGenetic modification of T cells redirected toward CS1 enhances eradication of myeloma cells.Clin Cancer Res 20 3989-4000 8/1/2014
  • Han C, Zhao R, Liu X, Srivastava A, Gong L, Mao H, Qu M, Zhao W, Yu J, Wang QEDDB2 suppresses tumorigenicity by limiting the cancer stem cell population in ovarian cancer.Mol Cancer Res 12 784-94 5/1/2014
  • Zhao R, Han C, Eisenhauer E, Kroger J, Zhao W, Yu J, Selvendiran K, Liu X, Wani AA, Wang QEDNA damage-binding complex recruits HDAC1 to repress Bcl-2 transcription in human ovarian cancer cells.Mol Cancer Res 12 370-80 3/1/2014
  • Wang QE, Han C, Zhao R, Wani G, Zhu Q, Gong L, Battu A, Racoma I, Sharma N, Wani AAp38 MAPK- and Akt-mediated p300 phosphorylation regulates its degradation to facilitate nucleotide excision repair.Nucleic Acids Res 41 1722-33 2/1/2013
  • Racoma IO, Meisen WH, Wang QE, Kaur B, Wani AAThymoquinone inhibits autophagy and induces cathepsin-mediated, caspase-independent cell death in glioblastoma cells.PLoS One 8 e72882 1/1/2013
  • Han C, Zhao R, Kroger J, Qu M, Wani AA, Wang QECaspase-2 short isoform interacts with membrane-associated cytoskeleton proteins to inhibit apoptosis.PLoS One 8 e67033 1/1/2013
  • Yu J, Peng Y, Wu LC, Xie Z, Deng Y, Hughes T, He S, Mo X, Chiu M, Wang QE, He X, Liu S, Grever MR, Chan KK, Liu ZCurcumin down-regulates DNA methyltransferase 1 and plays an anti-leukemic role in acute myeloid leukemia.PLoS One 8 e55934 1/1/2013

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 460 W. 10th Avenue, Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu