General Research InterestThe understanding of molecular mechanisms by which environmental agents can influence hormonal signaling and tumorigenesis.
Research DescriptionDr. Burd's lab focuses on the signaling of estrogen through its cognate receptor, the estrogen receptor. Estrogen signaling plays a central role in breast cancer development and progression and deregulated activity influences therapeutic relapse. In the lab, the aim is to understand the molecular mechanisms controlling the estrogen receptor’s activity and potentially how these mechanisms, when not properly maintained, influence breast cancer risk and therapeutic relapse. One of the core interests in the lab is to characterize the potential of environmental chemicals, called endocrine disruptors, to influence breast cancer risk.