Zui Pan PhD

Zui Pan PhD
Res Assoc ProfessorCollege of Medicinepan.361@osu.edu
398 Biomedical Research Tower 460 W 12th Avenue Columbus Ohio 43210
Phone:614-292-2213Fax: (614) 292-4350
  • Molecular Carcinogenesis and Chemoprevention

General Research Interest

Ca2+ channels, Esophageal cancers, Cancer prevention, Barrett’s esophagus, Ca2+ signaling in muscle cells

Research Description

The long-term goal of Dr. Pan’s laboratory is to search for effective prognostic biomarkers and potential therapeutic means for treatment of esophageal cancers by targeting Ca2+ signaling pathway. Of particular interests are Orai1, an important Ca2+ channel involved in cancer cell proliferation, migration, metastasis and apoptosis. The current effort is focused on understanding of the molecular mechanism underlying the function of Orai1 and its regulatory molecules in esophageal squamous cell carcinoma, adenocarcinoma and Barrett’s esophagus. Our experimental approach includes high-spatiotemporal resolution optical imaging, molecular and cellular biology as well as small rodent animal models.

Transinstitutional Work

Dr. Pan is collaborating with Dr. Kyle Perry, Assistant Professor of Surgery to evaluate novel prognostic biomarkers for Barrett’s esophagus and esophageal adenocarcinoma. She also works closely with Dr. Jianjie Ma in conducting pre-clinical studies on a potent pro-apoptotic peptide in treatment of various cancers.

Current Publications

  • Pan Z, Ma JOpen Sesame: treasure in store-operated calcium entry pathway for cancer therapy.Sci China Life Sci in press 12/7/2014
  • Shi N, Jin F, Zhang X, Clinton SK, Pan Z, Chen TOverexpression of human β-defensin 2 promotes growth and invasion during esophageal carcinogenesis.Oncotarget in press 9/5/2014
  • Pan Z, Brotto M, Ma JStore-operated Ca2+ entry in muscle physiology and diseases.BMB Rep 47 69-79 2/1/2014

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 460 W. 10th Avenue, Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu