Richard Bruno S PhD, RD

Richard Bruno S PhD, RD
Assoc ProfessorCollege of Education and Human Ecologybruno.27@osu.eduwebsite
325 Campbell Hall 1787 Neil Avenue Columbus OH 43210
Phone:(614) 292-5522Fax: (614) 292-4339
  • Molecular Carcinogenesis and Chemoprevention

General Research Interest

Bioavailability of polyphenols and vitamin E; Anti-inflammatory and antioxidant activities of green tea and vitamin E on hepatocellular insults resulting from obesity that lead to liver cancer

Research Description

The biochemical and molecular nutrition research conducted in Dr. Bruno’s laboratory aims to define the mechanisms regulating the bioavailability of dietary phytochemicals, particularly polyphenols such as quercetin and antioxidants including vitamin E, and the mechanisms by which these dietary agents protect against oxidative stress and pro-inflammatory responses that otherwise contribute to liver cancer resulting from nonalcoholic steatohepatitis (NASH). His work routinely utilizes model systems recapitulating oxidative stress and inflammatory responses observed in humans with the underlying goal of translating experimental findings into practical recommendations that promote optimal health. The research of his laboratory is currently directed at: 1) conducting vitamin E pharmacokinetic studies to define fractional turnover of α-tocopherol in patients with metabolic syndrome in order to better define dietary vitamin E requirements in populations having a high inflammatory burden, 2) validating nano-emulsion based delivery systems of polyphenols to enhance their bioavailability and putative bioactivity, and 3) defining Nrf2-dependent cytoprotective responses regulated by green tea that suppress hepatic NFκB-dependent pro-inflammatory responses that otherwise lead to hepatocellular injury implicated in liver cancer.

Current Publications

  • Guo Y, Mah E, Bruno RSQuercetin bioavailability is associated with inadequate plasma vitamin C status and greater plasma endotoxin in adults.Nutrition 30 1279-1286 11/1/2014
  • Tran TH, Guo Y, Song D, Bruno RS, Lu XQuercetin-containing self-nanoemulsifying drug delivery system for improving oral bioavailability.J Pharm Sci 103 840-52 3/1/2014

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu