Steven Clinton K MD, PhD

Steven Clinton K MD, PhD
ProfessorCollege of Medicineclinton.8@osu.edu
A456 Straling Loving Hall 320 W 10th Avenue Columbus Ohio 43210
Phone:614-293-2886Fax: (614) 293-7525
  • Molecular Carcinogenesis and Chemoprevention

Research Description

Dr. Clinton is a physician-scientist who has devoted his career to research in cancer etiology and prevention. His laboratory program has published extensively upon the role of dietary energy balance and obesity in cancer risk, in addition to a variety of foods associated with cancer prevention properties, such as hops, tomatoes, soy, and cruciferous vegetables (broccoli, cauliflower, cabbage), as well as several nutrients including vitamin D, calcium, omega-3 fatty acids, and vitamin E. His laboratory has expertise in molecular biology, cellular and experimental models of carcinogenesis, as well as human clinical trials. These studies are often done in collaboration with scientists in other disciplines at Ohio State, such as the College of Food, Agricultural and Environmental Sciences, in a coordinated "crops to clinic" research effort.

Current Publications

  • Focht BC, Lucas AR, Grainger E, Simpson C, Thomas-Ahner JM, Clinton SKThe Individualized Diet and Exercise Adherence Pilot Trial (IDEA-P) in prostate cancer patients undergoing androgen deprivation therapy: study protocol for a randomized controlled trial.Trials in press 354 9/9/2014
  • Shi N, Jin F, Zhang X, Clinton SK, Pan Z, Chen TOverexpression of human β-defensin 2 promotes growth and invasion during esophageal carcinogenesis.Oncotarget in press 9/5/2014
  • Mace TA, King SA, Ameen Z, Elnaggar O, Young G, Riedl KM, Schwartz SJ, Clinton SK, Knobloch TJ, Weghorst CM, Lesinski GBBioactive compounds or metabolites from black raspberries modulate T lymphocyte proliferation, myeloid cell differentiation and Jak/STAT signaling.Cancer Immunol Immunother 63 889-900 9/1/2014
  • Kopec RE, Cooperstone JL, Schweiggert RM, Young GS, Harrison EH, Francis DM, Clinton SK, Schwartz SJAvocado Consumption Enhances Human Postprandial Provitamin A Absorption and Conversion from a Novel High-β-Carotene Tomato Sauce and from Carrots.J Nutr 144 1158-66 8/1/2014
  • Gutierrez-Orozco F, Thomas-Ahner JM, Berman-Booty LD, Galley JD, Chitchumroonchokchai C, Mace T, Suksamrarn S, Bailey MT, Clinton SK, Lesinski GB, Failla MLDietary α-mangostin, a xanthone from mangosteen fruit, exacerbates experimental colitis and promotes dysbiosis in mice.Mol Nutr Food Res 58 1226-38 6/1/2014
  • Bolon B, Oglesbee MJ, Clinton SK, Kulp SK, Chen CS, Perle KM, Berman-Booty LD, Thomas-Ahner JMExtra-prostatic Transgene-associated Neoplastic Lesions in Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP) Mice.Toxicol Pathol in press 4/17/2014
  • Tan HL, Moran NE, Cichon MJ, Riedl KM, Schwartz SJ, Erdman JW Jr, Pearl DK, Thomas-Ahner JM, Clinton SKβ-Carotene-9',10'-oxygenase status modulates the impact of dietary tomato and lycopene on hepatic nuclear receptor-, stress-, and metabolism-related gene expression in mice.J Nutr 144 431-9 4/1/2014
  • Monk P, Lam E, Mortazavi A, Kendra K, Lesinski GB, Mace TA, Geyer S, Carson WE 3rd, Tahiri S, Bhinder A, Clinton SK, Olencki TA phase I study of high-dose interleukin-2 with sorafenib in patients with metastatic renal cell carcinoma and melanoma.J Immunother 37 180-6 4/1/2014
  • Zu K, Mucci L, Rosner BA, Clinton SK, Loda M, Stampfer MJ, Giovannucci EDietary lycopene, angiogenesis, and prostate cancer: a prospective study in the prostate-specific antigen era.J Natl Cancer Inst 106 djt430 2/1/2014
  • Gu J, Ahn-Jarvis JH, Riedl KM, Schwartz SJ, Clinton SK, Vodovotz YCharacterization of Black Raspberry Functional Food Products for Cancer Prevention Human Clinical Trials.J Agric Food Chem in press 12/27/2013
  • Moran NE, Clinton SK, Erdman JW JrDifferential bioavailability, clearance, and tissue distribution of the acyclic tomato carotenoids lycopene and phytoene in mongolian gerbils.J Nutr 143 1920-6 12/1/2013
  • Kasperzyk JL, Finn SP, Flavin R, Fiorentino M, Lis R, Hendrickson WK, Clinton SK, Sesso HD, Giovannucci EL, Stampfer MJ, Loda M, Mucci LAProstate-specific membrane antigen protein expression in tumor tissue and risk of lethal prostate cancer.Cancer Epidemiol Biomarkers Prev 22 2354-63 12/1/2013
  • Moran NE, Erdman JW Jr, Clinton SKComplex interactions between dietary and genetic factors impact lycopene metabolism and distribution.Arch Biochem Biophys 539 171-80 11/15/2013
  • Singh R, Mortazavi A, Telu KH, Nagarajan P, Lucas DM, Thomas-Ahner JM, Clinton SK, Byrd JC, Freitas MA, Parthun MRIncreasing the complexity of chromatin: functionally distinct roles for replication-dependent histone H2A isoforms in cell proliferation and carcinogenesis.Nucleic Acids Res 41 9284-95 11/1/2013
  • Moran NE, Rogers RB, Clinton SK, Erdman JW Jr, Lu CH, Conlon LE, Lila MABiosynthesis of highly enriched 13C-lycopene for human metabolic studies using repeated batch tomato cell culturing with 13C-glucose.Food Chem 139 631-9 8/15/2013
  • Telu KH, Abbaoui B, Thomas-Ahner JM, Zynger DL, Clinton SK, Freitas MA, Mortazavi AAlterations of histone H1 phosphorylation during bladder carcinogenesis.J Proteome Res 12 3317-26 7/5/2013
  • Focht BC, Clinton SK, Devor ST, Garver MJ, Lucas AR, Thomas-Ahner JM, Grainger EResistance exercise interventions during and following cancer treatment: a systematic review.J Support Oncol 11 45-60 6/1/2013
  • Zuniga KE, Clinton SK, Erdman JW JrThe interactions of dietary tomato powder and soy germ on prostate carcinogenesis in the TRAMP model.Cancer Prev Res (Phila) 6 548-57 6/1/2013
  • Berman-Booty LD, Chu PC, Thomas-Ahner JM, Bolon B, Wang D, Yang T, Clinton SK, Kulp SK, Chen CSSuppression of prostate epithelial proliferation and intraprostatic progrowth signaling in transgenic mice by a new energy restriction-mimetic agent.Cancer Prev Res (Phila) 6 232-41 3/1/2013
  • Thomas-Ahner JM, Li J, Riedl KM, Nontakham J, Suksumrarn S, Clinton SK, Kinghorn AD, Failla ML, Chitchumroonchokchai CAnti-tumorigenicity of dietary α-mangostin in an HT-29 colon cell xenograft model and the tissue distribution of xanthones and their phase II metabolites.Mol Nutr Food Res 57 203-11 2/1/2013
  • Yee LD, Agarwal D, Rosol TJ, Lehman A, Tian M, Hatton J, Heestand J, Belury MA, Clinton SKThe inhibition of early stages of HER-2/neu-mediated mammary carcinogenesis by dietary n-3 PUFAs.Mol Nutr Food Res 57 320-7 2/1/2013
  • Martin LK, Bekaii-Saab T, Serna D, Monk P, Clinton SK, Grever MR, Kraut EHA phase I dose escalation and pharmacodynamic study of SU5416 (semaxanib) combined with weekly cisplatin and irinotecan in patients with advanced solid tumors.Onkologie 36 657-60 1/1/2013
  • Bohn T, Blackwood M, Francis D, Tian Q, Schwartz SJ, Clinton SKBioavailability of phytochemical constituents from a novel soy fortified lycopene rich tomato juice developed for targeted cancer prevention trials.Nutr Cancer 65 919-29 1/1/2013
  • Abbaoui B, Riedl KM, Ralston RA, Thomas-Ahner JM, Schwartz SJ, Clinton SK, Mortazavi AInhibition of bladder cancer by broccoli isothiocyanates sulforaphane and erucin: characterization, metabolism, and interconversion.Mol Nutr Food Res 56 1675-87 11/1/2012

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu