Robert Curley, Jr. W PhD

Robert Curley, Jr. W PhD
Faculty EmeritusCollege of Pharmacycurley.1@osu.edu
606 Riffe Building 496 W 12th Avenue Columbus Ohio 43210
Phone:614-292-7628Fax: (614) 292-2435
  • Molecular Carcinogenesis and Chemoprevention

General Research Interest

Synthesis of Retinoids for Chemoprevention/Chemotherapy

Research Description

Dr. Curley has a longstanding interest in the chemistry and biochemistry of the fat-soluble vitamins, particularly vitamin A, and their bioactive metabolites with a particular emphasis on their potential as cancer preventive and treatment agents.

Transinstitutional Work

We have had a longstanding collaboration with Professor Hussein Abou-Issa (deceased) of Ohio State’s Department of Surgery. This collaboration on animal studies of our synthetic retinoid compounds in carcinogen treated rats has been continued with Dr. Galal Alshafie in Ohio State’s Department of Radiology. Our studies on the mechanism of action of our analogs and their teratogenicity are conducted in collaboration with Professor Margaret Clagett-Dame of the Department of Biochemistry of the University of Wisconsin-Madison. We have a new collaboration evolving with Professors Earl Harrison of Ohio State’s Department of Nutrition and Steven Schwartz of Ohio State’s Department of Food Science. In these studies we are exploring the occurrence and significance of metabolites of $-carotene and lycopene with a particular emphasis on their impact on carcinogenicity. Our primary role  in these studies is the synthesis and structural analysis of putative metabolites of the parent carotenoids.

Current Publications

  • Sun J, Narayanasamy S, Curley RW, Harrison EHβ-apo-13-Carotenone Regulates Retinoid X Receptor Transcriptional Activity Through Tetramerization of the Receptor.J Biol Chem in press 10/16/2014
  • dela Seña C, Riedl KM, Narayanasamy S, Curley RW, Schwartz SJ, Harrison EHThe human enzyme that converts dietary provitamin A carotenoids to vitamin A is a dioxygenase.J Biol Chem 289 13661-6 5/9/2014

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu