General Research InterestSynthesis of Retinoids for Chemoprevention/Chemotherapy
Research DescriptionDr. Curley has a longstanding interest in the chemistry and biochemistry of the fat-soluble vitamins, particularly vitamin A, and their bioactive metabolites with a particular emphasis on their potential as cancer preventive and treatment agents.
Transinstitutional WorkWe have had a longstanding collaboration with Professor Hussein Abou-Issa (deceased) of Ohio State’s Department of Surgery. This collaboration on animal studies of our synthetic retinoid compounds in carcinogen treated rats has been continued with Dr. Galal Alshafie in Ohio State’s Department of Radiology. Our studies on the mechanism of action of our analogs and their teratogenicity are conducted in collaboration with Professor Margaret Clagett-Dame of the Department of Biochemistry of the University of Wisconsin-Madison.
We have a new collaboration evolving with Professors Earl Harrison of Ohio State’s Department of Nutrition and Steven Schwartz of Ohio State’s Department of Food Science. In these studies we are exploring the occurrence and significance of metabolites of $-carotene and lycopene with a particular emphasis on their impact on carcinogenicity. Our primary role in these studies is the synthesis and structural analysis of putative metabolites of the parent carotenoids.