Robert A DiSilvestro PhD

Robert A DiSilvestro PhD
ProfessorColl of Education & Human Ecoldisilvestro.1@osu.edu
345 Campbell Hall 1787 Neil Avenue Columbus Ohio 43210
Phone:614-292-6848Fax: 614-292-8880
  • Molecular Carcinogenesis and Chemoprevention

General Research Interest

Chemoprevention by phytochemicals and minerals; body internal anti-inflammatory defense mechanisms

Research Description

Phytochemicals are food components from plants that are not strictly required for normal function, but can have health promoting properties.  These health promoting properties can include reducing cancer risk.  Examples of the mechanisms include antioxidant/anti-inflammatory actions, boosting the immune system, strengthening connective tissue, and raising internal production of carcinogen metabolizing enzymes.  My research considers the effects of certain phytochemicals on these processes.  A current project examines green tea phytochemicals in relationship to various anti-cancer defense mechanisms in pulmonary bronchoalveolar lavage fluid from humans.  Certain phytochemicals can work through the body’s own antioxidant/anti-inflammatory molecules.  Some of these molecules, such as the superoxide dismutase enzymes, require minerals for activity.  Thus, my research looks at how phytochemicals and minerals can work together.

Transinstitutional Work

My group and Phil Diaz of the Dorothy M Davis OSU Heart and Lung Institute are working together on a green tea lung cancer chemoprevention project.

Current Publications

  • DiSilvestro RA, Joseph EL, Zhang W, Raimo AE, Kim YMA randomized trial of copper supplementation effects on blood copper enzyme activities and parameters related to cardiovascular health.Metabolism 61(9) 1242-6 9/1/2012

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu