Mark Failla L PhD

Mark Failla L PhD
ProfessorColl of Education & Human Ecolfailla.3@osu.edu
262G Campbell Hall 1787 Neil Avenue Columbus Ohio 43210
Phone:614-688-1444Fax: (614) 292-8880
  • Molecular Carcinogenesis and Chemoprevention

Research Description

Dr. Failla and his research team are interested in the digestive stability, intestinal cell uptake, absorption, and functions of health-promoting compounds in foods. He primarily focuses on two families of compounds in plant foods, carotenoids and soy isoflavonoids. His research uses in vitro approaches to simulate digestion and study the uptake, metabolism, and transepithelial transport of bioactive compounds by human intestinal cells. He also employs cell models, animal models, and human and animal intervention trials

Current Publications

  • Ferruzzi MG, Goltz SR, Campbell WW, Failla ML, Chitchumronchokchai CUnsaturated fatty acids promote bioaccessibility and basolateral secretion of carotenoids and α-tocopherol by Caco-2 cells.Food Funct 5 1101-12 6/1/2014
  • Gutierrez-Orozco F, Thomas-Ahner JM, Berman-Booty LD, Galley JD, Chitchumroonchokchai C, Mace T, Suksamrarn S, Bailey MT, Clinton SK, Lesinski GB, Failla MLDietary α-mangostin, a xanthone from mangosteen fruit, exacerbates experimental colitis and promotes dysbiosis in mice.Mol Nutr Food Res 58 1226-38 6/1/2014
  • Thomas JL, Gushchina LV, Disilvestro D, Failla ML, Ziouzenkova O, Shen Q, Chitchumroonchokchai CAdipocyte reporter assays: application for identification of anti-inflammatory and antioxidant properties of mangosteen xanthones.Mol Nutr Food Res 58 239-47 2/1/2014
  • Frazier EA, Gracious B, Arnold LE, Failla M, Chitchumroonchokchai C, Habash D, Fristad MANutritional and safety outcomes from an open-label micronutrient intervention for pediatric bipolar spectrum disorders.J Child Adolesc Psychopharmacol 23 558-67 10/1/2013
  • Gutierrez-Orozco F, Failla MLBiological activities and bioavailability of mangosteen xanthones: a critical review of the current evidence.Nutrients 5 3163-83 8/1/2013
  • Serventi L, Chitchumroonchokchai C, Riedl KM, Kerem Z, Berhow MA, Vodovotz Y, Schwartz SJ, Failla MLSaponins from soy and chickpea: stability during beadmaking and in vitro bioaccessibility.J Agric Food Chem 61 6703-10 7/10/2013
  • Liu MJ, Bao S, Bolin ER, Failla ML, Knoell DL, Burris DL, Xu X, Sun Q, Killilea DW, Shen Q, Ziouzenkova O, Belury MAZinc deficiency augments leptin production and exacerbates macrophage infiltration into adipose tissue in mice fed a high-fat diet.J Nutr 143 1036-45 7/1/2013
  • Goltz SR, Sapper TN, Failla ML, Campbell WW, Ferruzzi MGCarotenoid bioavailability from raw vegetables and a moderate amount of oil in human subjects is greatest when the majority of daily vegetables are consumed at one meal.Nutr Res 33 358-66 5/1/2013
  • Gutierrez-Orozco F, Chitchumroonchokchai C, Lesinski GB, Suksamrarn S, Failla MLα-Mangostin: anti-inflammatory activity and metabolism by human cells.J Agric Food Chem 61 3891-900 4/24/2013
  • Victoria-Campos CI, Ornelas-Paz Jde J, Yahia EM, Failla MLEffect of the interaction of heat-processing style and fat type on the micellarization of lipid-soluble pigments from green and red pungent peppers (Capsicum annuum).J Agric Food Chem 61 3642-53 4/17/2013
  • Chitchumroonchokchai C, Thomas-Ahner JM, Li J, Riedl KM, Nontakham J, Suksumrarn S, Clinton SK, Kinghorn AD, Failla MLAnti-tumorigenicity of dietary α-mangostin in an HT-29 colon cell xenograft model and the tissue distribution of xanthones and their phase II metabolites.Mol Nutr Food Res 57 203-11 2/1/2013
  • Simmons AL, Chitchumroonchokchai C, Vodovotz Y, Failla MLIsoflavone retention during processing, bioaccessibility, and transport by Caco-2 cells: effects of source and amount of fat in a soy soft pretzel.J Agric Food Chem 60 12196-203 12/12/2012
  • Kamonpatana K, Giusti MM, Chitchumroonchokchai C, MorenoCruz M, Riedl KM, Kumar P, Failla MLSusceptibility of anthocyanins to ex vivo degradation in human saliva.Food Chem 135 738-47 11/15/2012

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu