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Manisha H. Shah MD

Manisha H. Shah MD
Assoc ProfessorCollege of Medicinemanisha.shah@osumc.edu
A441 Starling Loving Hall 320 W 10th Avenue Columbus OH 43210
Phone:614-293-8629Fax: 614-293-4372
  • Experimental Therapeutics

General Research Interest

Clinical research in Neuroendocrine cancers, Thyroid cancers and Adrenal Cancers.

Research Description

Our group focuses on discovering new targeted therapies for patients with Neuroendocrine cancers, Thyroid cancers and Adrenal Cancers. We offer phase II-III clinical trials in these types of cancers. We lead many national studies. We conduct pre-clinical studies to learn types of drugs and combination of drugs and apply that knowledge to design clinical trials. We also perform several tests on tumor genetics, tumor imaging, pharmacokinetics and pharmacodynamics of study drugs as part of our clinical trials.

Transinstitutional Work

We collaborate with other centers to perform clinical trials in Neuroendocrine cancers, Thyroid cancers and Adrenal Cancers.

Current Publications

  • Arrese D, McNally ME, Chokshi R, Feria-Arias E, Schmidt C, Klemanski D, Gregory G, Khabiri H, Shah M, Bloomston MExtrahepatic disease should not preclude transarterial chemoembolization for metastatic neuroendocrine carcinoma.Ann Surg Oncol 20(4) 1114-20 4/1/2013
  • Demetri GD, Garrett CR, Schöffski P, Shah MH, Verweij J, Leyvraz S, Hurwitz HI, Pousa AL, Le Cesne A, Goldstein D, Paz-Ares L, Blay JY, McArthur GA, Xu QC, Huang X, Harmon CS, Tassell V, Cohen DP, Casali PGComplete longitudinal analyses of the randomized, placebo-controlled, phase III trial of sunitinib in patients with gastrointestinal stromal tumor following imatinib failure.Clin Cancer Res 18(11) 3170-9 6/1/2012
  • Jones NB, Shah MH, Bloomston MLiver-directed therapies in patients with advanced neuroendocrine tumors.J Natl Compr Canc Netw 10(6) 765-74 6/1/2012
  • Wright CL, Werner JD, Tran JM, Gates VL, Rikabi AA, Shah MH, Salem RRadiation pneumonitis following yttrium-90 radioembolization: case report and literature review.J Vasc Interv Radiol 23(5) 669-74 5/1/2012
  • Ramaswamy B, Phelps MA, Baiocchi R, Bekaii-Saab T, Ni W, Lai JP, Wolfson A, Lustberg ME, Wei L, Wilkins D, Campbell A, Arbogast D, Doyle A, Byrd JC, Grever MR, Shah MHA dose-finding, pharmacokinetic and pharmacodynamic study of a novel schedule of flavopiridol in patients with advanced solid tumors.Invest New Drugs 30(2) 629-38 4/1/2012
  • Koh YW, Shah MH, Agarwal K, McCarty SK, Koo BS, Brendel VJ, Wang C, Porter K, Jarjoura D, Saji M, Ringel MDSorafenib and Mek inhibition is synergistic in medullary thyroid carcinoma in vitro.Endocr Relat Cancer 19(1) 29-38 2/1/2012
  • Caronia LM, Phay JE, Shah MHRole of BRAF in thyroid oncogenesis.Clin Cancer Res 17(24) 7511-7 12/15/2011
  • Liebner DA, Shah MHThyroid cancer: pathogenesis and targeted therapy.Ther Adv Endocrinol Metab 2(5) 173-95 10/1/2011