Jiayuh Lin PhD

Jiayuh Lin PhD
Assoc ProfessorCollege of MedicineJiayuh.Lin@nationwidechildrens.org
WA5020 Center for Childhood Cancer - CCRI 700 Children's Drive Columbus OH 43205
Phone:614-722-5086Fax: 614-722-5868
  • Experimental Therapeutics

General Research Interest

Our laboratory is working on the cancer biology and cancer therapy of STAT3 pathway in human cancer.

Research Description

STAT3 is frequently activated in many types of human cancer and play a role in cancer progression.   STAT3 is recognized as an attractive therapeutic target.   Our research focus is to develop small molecular inhibitors that target JAK2/STAT3 and IL-6/STAT3 as novel therapeutic target approaches in solid and blood cancers.

Transinstitutional Work

Collaborators to develop novel STAT3 and IL-6 inhibitors: Tom Li, Ph.D. (Division of Medicinal chemistry, College of Pharmacy) Chenglong Li, Ph.D. (Division of Medicinal chemistry, College of Pharmacy) Jim Fuchs, Ph.D. (Division of Medicinal chemistry, College of Pharmacy) Gregory Lesinki, Ph.D. (Internal Medicine, College of Medicine)

Current Publications

  • Bid HK, Roberts RD, Cam M, Audino A, Kurmasheva RT, Lin J, Houghton PJ, Cam H?Np63 Promotes Pediatric Neuroblastoma and Osteosarcoma by Regulating Tumor Angiogenesis.Cancer Res 74 320-9 1/1/2014
  • Bid HK, Kibler A, Phelps D, Manap S, Xiao L, Lin J, Capper D, Oswald D, Geier B, Dewire M, Smith PD, Kurmasheva RT, Mo X, Fernandez S, Houghton PJDevelopment, Characterization, and Reversal of Acquired Resistance to the MEK1 Inhibitor Selumetinib (AZD6244) in an In Vivo Model of Childhood Astrocytoma.Clin Cancer Res 19 6716-29 12/15/2013
  • Li L, Tang W, Wu X, Karnak D, Meng X, Thompson R, Hao X, Li Y, Qiao XT, Lin J, Fuchs J, Simeone DM, Chen ZN, Lawrence TS, Xu LHAb18G/CD147 Promotes pSTAT3-Mediated Pancreatic Cancer Development via CD44s.Clin Cancer Res 19 6703-15 12/15/2013
  • Wang W, Zhao C, Jou D, Lü J, Zhang C, Lin L, Lin JUrsolic acid inhibits the growth of colon cancer-initiating cells by targeting STAT3.Anticancer Res 33(10) 4279-84 10/1/2013

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu