Kalpana Ghoshal PhD

Kalpana Ghoshal PhD
Assoc ProfessorCollege of Medicineghoshal.1@osu.edu
646C Tzagournis Med Res Facility 420 W 12th Avenue Columbus Ohio 43210
Phone:614-292-8865Fax: 614-292-4118
  • Experimental Therapeutics

Current Publications

  • Hsu SH, Yu B, Wang X, Lu Y, Schmidt CR, Lee RJ, Lee LJ, Jacob ST, Ghoshal KCationic lipid nanoparticles for therapeutic delivery of siRNA and miRNA to murine liver tumor.Nanomedicine 9 1169-80 11/1/2013
  • Wang X, Yu B, Ren W, Mo X, Zhou C, He H, Jia H, Wang L, Jacob ST, Lee RJ, Ghoshal K, Lee LJEnhanced hepatic delivery of siRNA and microRNA using oleic acid based lipid nanoparticle formulations.J Control Release in press 10/8/2013
  • Hsu SH, Wang B, Kutay H, Bid H, Shreve J, Zhang X, Costinean S, Bratasz A, Houghton P, Ghoshal KHepatic Loss of miR-122 Predisposes Mice to Hepatobiliary Cyst and HCC upon Diethylnitrosamine Exposure.Am J Pathol in press 10/7/2013
  • Chu J, Deng Y, Benson DM Jr, He S, Hughes T, Zhang J, Peng Y, Mao H, Yi L, Ghoshal K, He X, Devine SM, Zhang X, Caligiuri MA, Hofmeister CC, Yu JCS1-specific chimeric antigen receptor (CAR)-engineered natural killer cells enhance in vitro and in vivo antitumor activity against human multiple myeloma.Leukemia in press 9/26/2013
  • Wang B, Hsu SH, Wang X, Kutay H, Bid HK, Yu J, Ganju R, Jacob S, Yuneva M, Ghoshal KReciprocal regulation of miR-122 and c-Myc in hepatocellular cancer: Role of E2F1 and TFDP2.Hepatology in press 8/28/2013
  • Hsu SH, Motiwala T, Roy S, Claus R, Mustafa M, Plass C, Freitas MA, Ghoshal K, Jacob STMethylation of the PTPRO gene in human hepatocellular carcinoma and identification of VCP as its substrate.J Cell Biochem 114(8) 1810-8 8/1/2013
  • Zhang M, Zhou X, Wang B, Yung BC, Lee LJ, Ghoshal K, Lee RJLactosylated gramicidin-based lipid nanoparticles (Lac-GLN) for targeted delivery of anti-miR-155 to hepatocellular carcinoma.J Control Release 168(3) 251-61 6/28/2013
  • He S, Chu J, Wu LC, Mao H, Peng Y, Alvarez-Breckenridge CA, Hughes T, Wei M, Zhang J, Yuan S, Sandhu S, Vasu S, Benson DM Jr, Hofmeister C, He X, Ghoshal K, Devine SM, Caligiuri MA, Yu JMicroRNAs activate natural killer cells through Toll-like receptor signaling.Blood 121(23) 4663-71 6/6/2013
  • Hsu SH, Ghoshal KMicroRNAs in Liver Health and Disease.Curr Pathobiol Rep 1(1) 53-62 3/1/2013
  • Yu B, Hsu SH, Zhou C, Wang X, Terp MC, Wu Y, Teng L, Mao Y, Wang F, Xue W, Jacob ST, Ghoshal K, Lee RJ, Lee LJLipid nanoparticles for hepatic delivery of small interfering RNA.Biomaterials 33(25) 5924-34 9/1/2012
  • Hsu SH, Wang B, Kota J, Yu J, Costinean S, Kutay H, Yu L, Bai S, La Perle K, Chivukula RR, Mao H, Wei M, Clark KR, Mendell JR, Caligiuri MA, Jacob ST, Mendell JT, Ghoshal KEssential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver.J Clin Invest 122(8) 2871-83 8/1/2012
  • Wang B, Hsu S, Frankel W, Ghoshal K, Jacob STStat3-mediated activation of microRNA-23a suppresses gluconeogenesis in hepatocellular carcinoma by down-regulating glucose-6-phosphatase and peroxisome proliferator-activated receptor gamma, coactivator 1 alpha.Hepatology 56(1) 186-97 7/1/2012

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu