Kalpana Ghoshal PhD

Kalpana Ghoshal PhD
Assoc ProfessorCollege of Medicineghoshal.1@osu.edu
646C Tzagournis Med Res Facility 420 W 12th Avenue Columbus Ohio 43210
Phone:614-292-8865Fax: (614) 292-4118
  • Translational Therapeutics

Research Description

Dr. Goshal’s lab focuses on elucidating the functions of microRNAs and the factors involved in DNA methylation / hydroxymethylation in liver biology and the consequence of their deregulation in liver disease such as alcoholic and nonalcoholic fatty liver disease, drug-induced liver toxicity and liver cancer. We utilize primary hepatocytes, cells culture and mouse models as well as diseased liver tissues from patients to better understand the role of these factors in liver biology and disease processes. 
The goal of the lab is to develop novel therapies for various liver diseases including hepatocellular cancer (HCC).

Current Publications

  • Eichhorn SW, Guo H, McGeary SE, Rodriguez-Mias RA, Shin C, Baek D, Hsu SH, Ghoshal K, Villén J, Bartel DPmRNA Destabilization Is the Dominant Effect of Mammalian MicroRNAs by the Time Substantial Repression Ensues.Mol Cell in press 9/24/2014
  • Devine SM, Zhang X, Caligiuri MA, Hofmeister CC, Yu J, Chu J, Deng Y, Benson DM, He S, Hughes T, Zhang J, Peng Y, Mao H, Yi L, Ghoshal K, He XCS1-specific chimeric antigen receptor (CAR)-engineered natural killer cells enhance in vitro and in vivo antitumor activity against human multiple myeloma.Leukemia 28 917-27 4/1/2014
  • Wang B, Hsu SH, Wang X, Kutay H, Bid HK, Yu J, Ganju RK, Jacob ST, Yuneva M, Ghoshal KReciprocal regulation of microRNA-122 and c-Myc in hepatocellular cancer: role of E2F1 and transcription factor dimerization partner 2.Hepatology 59 555-66 2/1/2014
  • Wang X, Yu B, Ren W, Mo X, Zhou C, He H, Jia H, Wang L, Jacob ST, Lee RJ, Ghoshal K, Lee LJEnhanced hepatic delivery of siRNA and microRNA using oleic acid based lipid nanoparticle formulations.J Control Release 172 690-8 12/28/2013
  • Hsu SH, Wang B, Kutay H, Bid H, Shreve J, Zhang X, Costinean S, Bratasz A, Houghton P, Ghoshal KHepatic loss of miR-122 predisposes mice to hepatobiliary cyst and hepatocellular carcinoma upon diethylnitrosamine exposure.Am J Pathol 183 1719-30 12/1/2013
  • Hsu SH, Yu B, Wang X, Lu Y, Schmidt CR, Lee RJ, Lee LJ, Jacob ST, Ghoshal KCationic lipid nanoparticles for therapeutic delivery of siRNA and miRNA to murine liver tumor.Nanomedicine 9 1169-80 11/1/2013
  • Hsu SH, Motiwala T, Roy S, Claus R, Mustafa M, Plass C, Freitas MA, Ghoshal K, Jacob STMethylation of the PTPRO gene in human hepatocellular carcinoma and identification of VCP as its substrate.J Cell Biochem 114 1810-8 8/1/2013
  • Zhang M, Zhou X, Wang B, Yung BC, Lee LJ, Ghoshal K, Lee RJLactosylated gramicidin-based lipid nanoparticles (Lac-GLN) for targeted delivery of anti-miR-155 to hepatocellular carcinoma.J Control Release 168 251-61 6/28/2013
  • Yu J, He S, Chu J, Wu LC, Mao H, Peng Y, Alvarez-Breckenridge CA, Hughes T, Wei M, Zhang J, Yuan S, Sandhu S, Vasu S, Benson DM Jr, Hofmeister CC, He X, Ghoshal K, Devine SM, Caligiuri MAMicroRNAs activate natural killer cells through Toll-like receptor signaling.Blood 121 4663-71 6/6/2013
  • Hsu SH, Ghoshal KMicroRNAs in Liver Health and Disease.Curr Pathobiol Rep 1 53-62 3/1/2013

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu