Wolfgang Sadee PhD

Wolfgang Sadee PhD
ChairCollege of Medicinesadee.1@osu.edu
5078 Graves Hall 333 W 10th Avenue Columbus Ohio 43210
Phone:614-292-1597Fax: (614) 292-7232
  • Translational Therapeutics

General Research Interest

Pharmacogenomics of cancer, cardiovascular diseases, and CNS disorders. Link to the OSU Program in Pharmacogenomics: http://pharmacogenomics.osu.edu/.

Research Description

Dr. Sadee's research focuses on individual variability in gene expression, as a main cause of genetic differences in drug response and toxicity. His laboratory also uses chemogenomics approaches in drug discovery and biomarker development

Transinstitutional Work

The Program in Pharmacogenomics supports multiple clinical trials, initiated upon discovery of novel regulatory polymorphisms with likely clinical relevance. Clinicla trials are ongoing with collaborators at the OSU CCC, the OSU Dorothy Davis Heart and Lung Research Institute and with multiple sites extramurally.

Current Publications

  • Sadee W, Hartmann K, Seweryn M, Pietrzak M, Handelman SK, Rempala GAMissing heritability of common diseases and treatments outside the protein-coding exome.Hum Genet in press 8/9/2014
  • Smith RM, Banks W, Hansen E, Sadee W, Herman GEFamily-Based Clinical Associations and Functional Characterization of the Serotonin 2A Receptor Gene (HTR2A) in Autism Spectrum Disorder.Autism Res 7 459-67 8/1/2014
  • Sadee W, Gadow KD, Pinsonneault JK, Perlman GAssociation of dopamine gene variants, emotion dysregulation and ADHD in autism spectrum disorder.Res Dev Disabil 35 1658-65 7/1/2014
  • Ding B, Kotti S, van Zuydam NR, Papp AC, Danchin N, Donnelly L, Morris AD, Chasman DI, Doevendans PA, Klungel OH, Ridker PM, van Gilst WH, Simon T, Nyberg F, Palmer CN, Sadee W, Leusink M, Onland-Moret NC, Asselbergs FW, van der Harst P, de Bakker PI, de Boer A, Verstuyft C, Maitland-van der Zee AHCholesteryl ester transfer protein polymorphisms, statin use, and their impact on cholesterol levels and cardiovascular events.Clin Pharmacol Ther 95 314-20 3/1/2014
  • Suhy A, Hartmann K, Newman L, Papp A, Toneff T, Hook V, Sadee WGenetic variants affecting alternative splicing of human cholesteryl ester transfer protein.Biochem Biophys Res Commun 443 1270-4 1/24/2014
  • Wang D, Poi MJ, Sun X, Gaedigk A, Leeder JS, Sadee WCommon CYP2D6 polymorphisms affecting alternative splicing and transcription: long-range haplotypes with two regulatory variants modulate CYP2D6 activity.Hum Mol Genet 23 268-78 1/1/2014
  • Di Giorgio A, Smith RM, Fazio L, D'Ambrosio E, Gelao B, Tomasicchio A, Selvaggi P, Taurisano P, Quarto T, Masellis R, Rampino A, Caforio G, Popolizio T, Blasi G, Sadee W, Bertolino ADRD2/CHRNA5 Interaction on Prefrontal Biology and Physiology during Working Memory.PLoS One 9 e95997 1/1/2014
  • Pinsonneault JK, Sullivan D, Sadee W, Soares CN, Hampson E, Steiner MAssociation study of the estrogen receptor gene ESR1 with postpartum depression--a pilot study.Arch Womens Ment Health 16 499-509 12/1/2013
  • Geier EG, Chen EC, Webb A, Papp AC, Yee SW, Sadee W, Giacomini KMProfiling solute carrier transporters in the human blood-brain barrier.Clin Pharmacol Ther 94 636-9 12/1/2013
  • Sadee WBridging material and biological sciences: the legacy of Hans Peter Merkle.Eur J Pharm Biopharm 85 3-4 9/1/2013
  • Sadee WGene-gene-environment interactions between drugs, transporters, receptors, and metabolizing enzymes: Statins, SLCO1B1, and CYP3A4 as an example.J Pharm Sci 102 2924-9 9/1/2013
  • Shuldiner AR, Relling MV, Peterson JF, Hicks JK, Freimuth RR, Sadee W, Pereira NL, Roden DM, Johnson JA, Klein TE, Greeson F, Gaur A, Reiss U, Huettel A, Cheng C, Gajjar A, Pappo A, Howard S, Hudson M, Pui CH, Jeha S, Evans WE, Broeckel U, Altman RB, Gong L, Whirl-Carrillo M, Klein TE, Sadee W, Manickam K, Sweet KM, Embi PJ, Roden D, Peterson J, Denny J, Schildcrout J, Bowton E, Pulley J, Beller M, Pharmacogenomics Research Network Translational Pharmacogenetics Program Group, Shuldiner AR, Vesely M, Robinson SW, Ambulos N Jr, Stass SA, Kelemen MD, Brown LA, Pollin TI, Beitelshees AL, Zhao RY, Pakyz RE, Palmer K, Alestock T, O'Neill C, Maloney K, Branham A, Sewell D, Relling MV, Crews K, Hoffman J, Cross S, Haidar C, Baker D, Hicks JK, Bell G, Mitchell J, Danciu I, Price L, Pereira NL, Weinshilboum R, Wang L, Johnson JA, Nelson D, Clare-Salzler M, Elsey A, Burkley B, Langaee T, Liu F, Nessl D, Dong HJ, Lesko L, Freimuth RR, Chute CGThe Pharmacogenomics Research Network Translational Pharmacogenetics Program: overcoming challenges of real-world implementation.Clin Pharmacol Ther 94 207-10 8/1/2013
  • Shuldiner AR, Relling MV, Peterson JF, Hicks JK, Freimuth RR, Sadee W, Pereira NL, Roden DM, Johnson JA, Klein TE, Greeson F, Gaur A, Reiss U, Huettel A, Cheng C, Gajjar A, Pappo A, Howard S, Hudson M, Pui CH, Jeha S, Evans WE, Broeckel U, Altman RB, Gong L, Whirl-Carrillo M, Klein TE, Sadee W, Manickam K, Sweet KM, Embi PJ, Roden D, Peterson J, Denny J, Schildcrout J, Bowton E, Pulley J, Beller M, Pharmacogenomics Research Network Translational Pharmacogenetics Program Group, Shuldiner AR, Vesely M, Robinson SW, Ambulos N Jr, Stass SA, Kelemen MD, Brown LA, Pollin TI, Beitelshees AL, Zhao RY, Pakyz RE, Palmer K, Alestock T, O'Neill C, Maloney K, Branham A, Sewell D, Relling MV, Crews K, Hoffman J, Cross S, Haidar C, Baker D, Hicks JK, Bell G, Mitchell J, Danciu I, Price L, Pereira NL, Weinshilboum R, Wang L, Johnson JA, Nelson D, Clare-Salzler M, Elsey A, Burkley B, Langaee T, Liu F, Nessl D, Dong HJ, Lesko L, Freimuth RR, Chute CGThe Pharmacogenomics Research Network Translational Pharmacogenetics Program: overcoming challenges of real-world implementation.Clin Pharmacol Ther 94 207-10 8/1/2013
  • Webb A, Papp AC, Sanford JC, Huang K, Parvin JD, Sadee WExpression of mRNA transcripts encoding membrane transporters detected with whole transcriptome sequencing of human brain and liver.Pharmacogenet Genomics 23 269-78 5/1/2013
  • Smith RM, Papp AC, Webb A, Ruble CL, Munsie LM, Nisenbaum LK, Kleinman JE, Lipska BK, Sadee WMultiple regulatory variants modulate expression of 5-hydroxytryptamine 2A receptors in human cortex.Biol Psychiatry 73 546-54 3/15/2013
  • Shapiro C, Andreassen PR, Otterson GA, Villalona-Calero MA, Duan W, Gao L, Zhao W, Leon M, Sadee W, Webb A, Resnick K, Wu X, Ramaswamy B, Cohn DEAssessment of FANCD2 nuclear foci formation in paraffin-embedded tumors: a potential patient-enrichment strategy for treatment with DNA interstrand crosslinking agents.Transl Res 161 156-64 3/1/2013
  • Azad AK, Curtis A, Papp A, Webb A, Knoell D, Sadee W, Schlesinger LSAllelic mRNA expression imbalance in C-type lectins reveals a frequent regulatory SNP in the human surfactant protein A (SP-A) gene.Genes Immun 14 99-106 3/1/2013
  • Sanford JC, Guo Y, Sadee W, Wang DRegulatory polymorphisms in CYP2C19 affecting hepatic expression.Drug Metabol Drug Interact 28 23-30 1/1/2013
  • Kitzmiller JP, Sullivan DM, Phelps MA, Wang D, Sadee WCYP3A4/5 combined genotype analysis for predicting statin dose requirement for optimal lipid control.Drug Metabol Drug Interact 28 59-63 1/1/2013
  • Sullivan D, Pinsonneault JK, Papp AC, Zhu H, Lemeshow S, Mash DC, Sadee WDopamine transporter DAT and receptor DRD2 variants affect risk of lethal cocaine abuse: a gene-gene-environment interaction.Transl Psychiatry 3 e222 1/1/2013
  • Smith RM, Webb A, Papp AC, Newman LC, Handelman SK, Suhy A, Mascarenhas R, Oberdick J, Sadee WWhole transcriptome RNA-Seq allelic expression in human brain.BMC Genomics 14 571 1/1/2013
  • Sadee WThe relevance of "missing heritability " in pharmacogenomics.Clin Pharmacol Ther 92 428-30 10/1/2012
  • Azad AK, Sadee W, Schlesinger LSInnate immune gene polymorphisms in tuberculosis.Infect Immun 80 3343-59 10/1/2012

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu