Wolfgang Sadee PhD

Wolfgang Sadee PhD
ChairCollege of Medicinesadee.1@osu.edu
5078 Graves Hall 333 W 10th Avenue Columbus Ohio 43210
Phone:614-292-1597Fax: 614-292-7232
  • Experimental Therapeutics

General Research Interest

Pharmacogenomics of cancer, cardiovascular diseases, and CNS disorders. Link to the OSU Program in Pharmacogenomics: http://pharmacogenomics.osu.edu/.

Research Description

Wolfgang Sadee is a Professor of Pharmacology. His research focuses on individual variability in gene expression, as a main cause of genetic differences in drug response and toxicity. His laboratory also uses chemogenomics approaches in drug discovery and biomarker development

Transinstitutional Work

The Program in Pharmacogenomics supports multiple clinical trials, initiated upon discovery of novel regulatory polymorphisms with likely clinical relevance. Clinicla trials are ongoing with collaborators at the OSU CCC, the OSU Dorothy Davis Heart and Lung Research Institute and with multiple sites extramurally.

Current Publications

  • Sadee WCommon CYP2D6 polymorphisms affecting alternative splicing and transcription: long-range haplotypes with two regulatory variants modulate CYP2D6 activity.Hum Mol Genet 23 268-78 1/1/2014
  • Smith RM, Webb A, Papp AC, Newman LC, Handelman SK, Suhy A, Mascarenhas R, Oberdick J, Sadee WWhole transcriptome RNA-Seq allelic expression in human brain.BMC Genomics 14 571 8/22/2013
  • Villalona-Calero MAAssessment of FANCD2 nuclear foci formation in paraffin-embedded tumors: a potential patient-enrichment strategy for treatment with DNA interstrand crosslinking agents.Transl Res 161(3) 156-64 3/1/2013
  • Azad AK, Sadee W, Schlesinger LSInnate immune gene polymorphisms in tuberculosis.Infect Immun 80(10) 3343-59 10/1/2012
  • Barrie ES, Smith RM, Sanford JC, Sadee WmRNA transcript diversity creates new opportunities for pharmacological intervention.Mol Pharmacol 81(5) 620-30 5/1/2012

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu