Wolfgang Sadee PhD
Wolfgang Sadee PhD
5078 Graves Hall 333 W 10th Avenue Columbus OH 43210
- Experimental Therapeutics
General Research InterestPharmacogenomics of cancer, cardiovascular diseases, and CNS disorders. Link to the OSU Program in Pharmacogenomics: http://pharmacogenomics.osu.edu/.
Research DescriptionWolfgang Sadee is a Professor of Pharmacology. His research focuses on individual variability in gene expression, as a main cause of genetic differences in drug response and toxicity. His laboratory also uses chemogenomics approaches in drug discovery and biomarker development
Transinstitutional WorkThe Program in Pharmacogenomics supports multiple clinical trials, initiated upon discovery of novel regulatory polymorphisms with likely clinical relevance. Clinicla trials are ongoing with collaborators at the OSU CCC, the OSU Dorothy Davis Heart and Lung Research Institute and with multiple sites extramurally.
Duan W, Gao L, Zhao W, Leon M, Sadee W, Webb A, Resnick K, Wu X, Ramaswamy B, Cohn DE, Shapiro C, Andreassen PR, Otterson GA, Villalona-Calero MAAssessment of FANCD2 nuclear foci formation in paraffin-embedded tumors: a potential patient-enrichment strategy for treatment with DNA interstrand crosslinking agents.Transl Res 161(3) 156-64 3/1/2013
Azad AK, Sadee W, Schlesinger LSInnate immune gene polymorphisms in tuberculosis.Infect Immun 80(10) 3343-59 10/1/2012
Barrie ES, Smith RM, Sanford JC, Sadee WmRNA transcript diversity creates new opportunities for pharmacological intervention.Mol Pharmacol 81(5) 620-30 5/1/2012
Wang D, Para MF, Koletar SL, Sadee WHuman N-acetyltransferase 1 *10 and *11 alleles increase protein expression through distinct mechanisms and associate with sulfamethoxazole-induced hypersensitivity.Pharmacogenet Genomics 21(10) 652-64 10/1/2011
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