Research DescriptionThe general theme of our research is the synthesis of complex, biologically active organic molecules based upon natural product templates. Natural product targets are chosen that provide maximal synergy among the implementation of synthetic strategies, the development of new methods, and the potential for biological applications. Although target oriented complex molecule synthesis is emphasized, enabling synthetic methods derive from particular challenges encountered in the pursuit of novel tactics and strategies. Current projects span various structural classes and biological activities of the synthetic targets. These include protein serine / threonine phosphatase inhibitors based upon members of the okadaic acid class, the potent anticancer natural product phorboxazole A, the marine biotoxin azaspiracid, and a variety of smaller molecules.