Chenglong Li PhD

Chenglong Li PhD
Assoc ProfessorCollege of Pharmacyli.728@osu.edu
612 Riffe Building 496 W 12th Avenue Columbus Ohio 43210
Phone:614-247-8786Fax: 614-292-2435
  • Experimental Therapeutics

General Research Interest

Structure-based drug design, Computational drug design and discovery, Molecular recognition, Computational chemistry, X-ray protein crystallography.

Research Description

My research focus is drug-target interaction at the molecular level. I combine computational molecular design with X-ray crystallography to do structure-based drug design and discovery. Currently, my cancer related projects are: 1) IL-6/JAK2/STAT3 signaling pathway. The design focus is to target the STAT3 SH2 domain to prevent STAT3 phosphorylation and dimerization; and to disrupt IL-6/IL-6R/gp130 functional complex. 2) DNMT1 and PRMT5. The design focus is to inhibit DNMT1 and PRMT5 catalytic sites from DNA and histone epigenetic methylations

Transinstitutional Work

Current trans-institutional work include: 1) collaborations with Drs. Tushar Patel, Greg Lesinski and Don Benson at College of Medicine, and Dr. Jiayuh Lin at the Nationwide Children’s hospital Columbus on anti-cancer drug discovery targeting IL-6/STAT3 oncogenic pathway; 2) collaboration with Dr. Rob Baiocchi at College of Medicine on anti-cancer drug discovery targeting PRMT5 epigenetic enzyme; 3) collaboration with Dr. Xiaodong Wang at the University of Toledo on drug design targeting CFTR to fight cystic fibrosis.

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu