Jeffrey J Chalmers PhD
Jeffrey J Chalmers PhD
333B Koffolt Laboratories 140 W 19th Avenue Columbus OH 43210
- Experimental Therapeutics
General Research InterestBioengineering, Biochemical Engineering, Biomedical Engineering
Research DescriptionThe research conducted in laboratories that I oversee involved the development of fundamental understanding and applications of the interaction of hydrodynamic and magnetic forces and cells. This work can range from the development of fundamental mathematical relationship describing physical phenomena to the development of simple, robust instruments for use in a clinical setting.
Transinstitutional WorkThe Chalmers laboratory, in collaboration with Dr. Maciej Zborowski are developing magnetic cell separation instrumentation that is being used in collaboration with several clinical laboratories at the Cleveland Clinic and The James Cancer Hospital to detect circulating tumor cells in the blood of cancer patients.
Wu Y, Deighan CJ, Miller BL, Balasubramanian P, Lustberg MB, Zborowski M, Chalmers JJIsolation and analysis of rare cells in the blood of cancer patients using a negative depletion methodology.Methods 64(2) 169-82 12/1/2013
Chen A, Byvank T, Chang WJ, Bharde A, Vieira G, Miller BL, Chalmers JJ, Bashir R, Sooryakumar ROn-chip magnetic separation and encapsulation of cells in droplets.Lab Chip 13(6) 1172-81 3/21/2013
Jin X, Chalmers JJ, Zborowski MIron transport in cancer cell culture suspensions measured by cell magnetophoresis.Anal Chem 84(10) 4520-6 5/15/2012
Lustberg M, Jatana KR, Zborowski M, Chalmers JJEmerging technologies for CTC detection based on depletion of normal cells.Recent Results Cancer Res 195 97-110 1/1/2012
Garcia-Villa A, Balasubramanian P, Miller BL, Lustberg MB, Ramaswamy B, Chalmers JJAssessment of γ-H2AX levels in circulating tumor cells from patients receiving chemotherapy.Front Oncol 2 128 1/1/2012
Chalmers JJAssessment of γ-H2AX levels in circulating tumor cells from patients receiving chemotherapy.Front Oncol 2 128 1/1/2012
Balasubramanian P, Lang JC, Jatana KR, Miller B, Ozer E, Old M, Schuller DE, Agrawal A, Teknos TN, Summers TA Jr, Lustberg MB, Zborowski M, Chalmers JJMultiparameter analysis, including EMT markers, on negatively enriched blood samples from patients with squamous cell carcinoma of the head and neck.PLoS One 7(7) e42048 1/1/2012
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