Naduparambil Jacob PhD
Naduparambil Jacob PhD
366 Wiseman Hall 400 W 12th Avenue Columbus OH 43210
- Experimental Therapeutics
General Research InterestTargeting mitotic machinery (Aurora B kinase and Survivin) in cancers, DNA double strand break repair, Radiation Biodosimetry, Radio-protectors and Radio-sensitizers.
Research DescriptionMy research focus/areas of interests include:
a) Biomarkers for early prediction of the delayed effects of normal tissue injury following radiation disaster or therapeutic exposure: The ultimate goal is to develop non-invasive serum/urine based biodosimetry and therapeutic strategies for timely intervention prior to expression of the disease.
b) Mechanisms of therapeutic resistance in malignant brain tumors: We are interested in the epigenetic modulators which define the competence of chromatin in DNA repair and understanding how it varies in normal tissue, radiation sensitive and resistant tumor tissues, with emphasis on GBM. The ultimate goal is to develop novel/ improved strategies for radio-sensitization of cancer cells, protecting normal cells and thereby achieving better therapeutic ratio.
c) Targeting the mitotic machinery in cancers: In collaboration with investigators at OSU College of Pharmacy, we have developed and tested several novel small molecules that inhibit survivin function in the Chromosomal Passenger Complex (CPC) and its association with Aurora-B kinase, another critical regulator of mitotic progression. We are currently investigating the efficacy of these agents.
d) Investigate the therapeutic, radio-protective and radio-sensitizing effects of selected natural products in mouse models.
Harshman SW, Chen MM, Branson OE, Jacob NK, Johnson AJ, Byrd JC, Freitas MAIsolation and analysis of linker histones across cellular compartments.J Proteomics 91 595-604 10/8/2013
Jacob NK, Cooley JV, Yee TN, Jacob J, Alder H, Wickramasinghe P, Maclean KH, Chakravarti AIdentification of sensitive serum microRNA biomarkers for radiation biodosimetry.PLoS One 8(2) e57603 1/1/2013
Jacob N, Cooley JV, Shirai K, Chakravarti ASurvivin splice variants are not essential for mitotic progression or inhibition of apoptosis induced by doxorubicin and radiation.Onco Targets Ther 5 7-20 1/1/2012
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