Samson Jacob T. PhD

Samson Jacob T. PhD
ProfessorCollege of Medicinejacob.42@osu.eduwebsite
646A Tzagournis Med Res Facility 420 W 12th Avenue Columbus Ohio 43210
Phone:614-688-5494Fax: (614) 688-5600
  • Administrative
  • Translational Therapeutics

Research Description

Dr. Jacob’s research program focuses on three areas: (1) Epigenetic silencing of tumor suppressors at different stages of tumorigenesis using cells in culture and animal models with emphasis on mechanisms and therapeutic interventions in human cancer; (2) Delineating the role of microRNAs in the initiation and progression of hepatocellular carcinoma and breast cancer, and in resistance to potent anticancer drugs, and applications in therapy.

Current Publications

  • Datta J, Yu B, Gordon K, Haseley A, Patton JT, Smith PL, Ryu J, Zhang X, Mo X, Marcucci G, Nuovo G, Kwon CH, Byrd JC, Chiocca EA, Li C, Sif S, Jacob S, Lawler S, Kaur B, Baiocchi RA, Yan F, Alinari L, Lustberg ME, Martin LK, Cordero-Nieves HM, Banasavadi-Siddegowda Y, Virk S, Barnholtz-Sloan J, Bell EH, Wojton J, Jacob NK, Chakravarti A, Nowicki MO, Wu X, Lapalombella RGenetic validation of the protein arginine methyltransferase PRMT5 as a candidate therapeutic target in glioblastoma.Cancer Res 74 1752-65 3/15/2014
  • Wang B, Hsu SH, Wang X, Kutay H, Bid HK, Yu J, Ganju RK, Jacob ST, Yuneva M, Ghoshal KReciprocal regulation of microRNA-122 and c-Myc in hepatocellular cancer: role of E2F1 and transcription factor dimerization partner 2.Hepatology 59 555-66 2/1/2014
  • Reyes RK, Motiwala T, Jacob STRegulation of glucose metabolism in hepatocarcinogenesis by microRNAs.Gene Expr 16 85-92 1/1/2014
  • Wang X, Yu B, Ren W, Mo X, Zhou C, He H, Jia H, Wang L, Jacob ST, Lee RJ, Ghoshal K, Lee LJEnhanced hepatic delivery of siRNA and microRNA using oleic acid based lipid nanoparticle formulations.J Control Release 172 690-8 12/28/2013
  • Hsu SH, Yu B, Wang X, Lu Y, Schmidt CR, Lee RJ, Lee LJ, Jacob ST, Ghoshal KCationic lipid nanoparticles for therapeutic delivery of siRNA and miRNA to murine liver tumor.Nanomedicine 9 1169-80 11/1/2013
  • Hsu SH, Motiwala T, Roy S, Claus R, Mustafa M, Plass C, Freitas MA, Ghoshal K, Jacob STMethylation of the PTPRO gene in human hepatocellular carcinoma and identification of VCP as its substrate.J Cell Biochem 114 1810-8 8/1/2013
  • Gamage SA, Brooke DG, Redkar S, Datta J, Jacob ST, Denny WAStructure-activity relationships for 4-anilinoquinoline derivatives as inhibitors of the DNA methyltransferase enzyme DNMT1.Bioorg Med Chem 21 3147-53 6/1/2013
  • Santhanam R, Dorrance AM, Walker C, Hoellerbauer P, Caligiuri MA, Byrd JC, Chen CS, James Lee L, Jacob S, Mrózek K, Bloomfield CD, Blum W, Garzon R, Schwind S, Marcucci G, Mims A, Walker AR, Huang X, Sun J, Wang H, Tarighat SS, Chan KK, Klisovic RB, Perrotti DIncreased anti-leukemic activity of decitabine via AR-42-induced upregulation of miR-29b: a novel epigenetic-targeting approach in acute myeloid leukemia.Leukemia 27 871-8 4/1/2013
  • Yan P, Frankhouser D, Murphy M, Tam HH, Rodriguez B, Curfman J, Trimarchi M, Geyer S, Wu YZ, Whitman SP, Metzeler K, Walker A, Klisovic R, Jacob S, Grever MR, Byrd JC, Bloomfield CD, Garzon R, Blum W, Caligiuri MA, Bundschuh R, Marcucci GGenome-wide methylation profiling in decitabine-treated patients with acute myeloid leukemia.Blood 120 2466-74 9/20/2012
  • Yu B, Hsu SH, Zhou C, Wang X, Terp MC, Wu Y, Teng L, Mao Y, Wang F, Xue W, Jacob ST, Ghoshal K, Lee RJ, Lee LJLipid nanoparticles for hepatic delivery of small interfering RNA.Biomaterials 33 5924-34 9/1/2012

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu