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Robert J. Lee PhD

Robert J. Lee PhD
ProfessorCollege of Pharmacylee@pharmacy.ohio-state.edu
542 Parks Hall 500 W 12th Avenue Columbus OH 43210
Phone:614-292-4172Fax: 614-292-7766
  • Experimental Therapeutics

General Research Interest

Targeted drug delivery systems. Liposomes and nanoparticles. Delivery systems for genes, antisense oligos, siRNA and miRNA.  Targeted imaging and therapeutic agents for tumors.  Novel bioconjugates.

Research Description

Robert J. Lee, Ph.D., Professor of Pharmaceutics, is a member of the OSU Comprehensive Cancer Center, the OSU Nanotechnology Center NSF-NSEC and a faculty at OSU College of Pharmacy since 1997 (tenured since 2002). He is an expert on targeted nanoparticle and liposomal drug delivery systems. He obtained his Ph.D. in Biochemistry at Purdue University, worked as a Senior Scientist at GeneMedicine Inc. in 1995-1996 and was involved in R&D of gene therapy based on lipid nanoparticles.  He then served as Vice President of R&D at Endocyte, Inc., where he was involved in the successful effort in taking 111In-DTPA-folate into a Phase I/II clinical trial. At OSU, Dr. Lee has published ~ 80 original research articles, reviews, and book chapters and was inventor on several patents in the area of nanomedicine.  He was the PI or co-PI on several NIH R01, R21, R43, R44 grants and grants from Leukemia Lymphoma Society, American Cancer Society, and DOD’s Congressional Directed Medical Research Program (CDMRP) in breast cancer.  He regularly serves on NCI grant review panels.

Transinstitutional Work

Dr. Lee had a close collaboration with Dr. Manohar Ratnam at the University of Toledo Medical School for a number of years. He is involved in the OSU NSEC, which is a multi-institutional center. Dr. Lee has very close collaborations with several colleagues in other colleges, including College of Medicine and Public Health, Biological Sciences and Veterinary Biosciences.

Current Publications

  • Zhang M, Zhou X, Wang B, Yung BC, Lee LJ, Ghoshal K, Lee RJLactosylated gramicidin-based lipid nanoparticles (Lac-GLN) for targeted delivery of anti-miR-155 to hepatocellular carcinoma.J Control Release 168(3) 251-61 6/28/2013
  • Hsu SH, Yu B, Wang X, Lu Y, Schmidt CR, Lee RJ, Lee LJ, Jacob ST, Ghoshal KCationic Lipid Nanoparticles for Therapeutic Delivery of siRNA and miRNA to Murine Liver Tumor.Nanomedicine in press 5/30/2013
  • Yu B, Mao Y, Yuan Y, Yue C, Wang X, Mo X, Jarjoura D, Paulaitis ME, Lee RJ, Byrd JC, Lee LJ, Muthusamy NTargeted drug delivery and cross-linking induced apoptosis with anti-CD37 based dual-ligand immunoliposomes in B chronic lymphocytic leukemia cells.Biomaterials in press 5/28/2013
  • Huang X, Schwind S, Yu B, Santhanam R, Wang H, Hoellerbauer P, Mims A, Klisovic RB, Walker A, Chan KK, Blum W, Perrotti D, Byrd JC, Bloomfield CD, Caligiuri MA, Lee RJ, Garzon R, Muthusamy N, Lee LJ, Marcucci GTargeted delivery of microRNA-29b by transferrin-conjugated anionic lipopolyplex nanoparticles: a novel therapeutic strategy in acute myeloid leukemia.Clin Cancer Res 19(9) 2355-67 5/1/2013
  • Wu Y, Crawford M, Mao Y, Lee RJ, Davis IC, Elton TS, Lee LJ, Nana-Sinkam SPTherapeutic Delivery of MicroRNA-29b by Cationic Lipoplexes for Lung Cancer.Mol Ther Nucleic Acids 2 e84 4/16/2013
  • Povoski SP, Chapman GJ, Murrey DA, Lee R, Martin EW, Hall NCIntraoperative detection of ¹⁸F-FDG-avid tissue sites using the increased probe counting efficiency of the K-alpha probe design and variance-based statistical analysis with the three-sigma criteria.BMC Cancer 13 98 3/4/2013
  • Mao Y, Triantafillou G, Hertlein E, Towns WH, Stefanovski M, Mo X, Jarjoura D, Phelps MA, Marcucci G, Lee LJ, Goldenberg DM, Lee RJ, John BC, Muthusamy NMilatuzumab-conjugated liposomes as targeted dexamethasone carriers for therapeutic delivery in CD74+ B-cell malignancies.Clin Cancer Res 19(2) 347-56 1/15/2013
  • Yu B, Mao Y, Bai LY, Herman SE, Wang X, Ramanunni A, Jin Y, Mo X, Cheney C, Chan KK, Jarjoura D, Marcucci G, Lee RJ, Byrd JC, Lee LJ, Muthusamy NTargeted nanoparticle delivery overcomes off-target immunostimulatory effects of oligonucleotides and improves therapeutic efficacy in chronic lymphocytic leukemia.Blood 121(1) 136-47 1/3/2013
  • Piao L, Li H, Teng L, Yung BC, Sugimoto Y, Brueggemeier RW, Lee RJHuman serum albumin-coated lipid nanoparticles for delivery of siRNA to breast cancer.Nanomedicine 9(1) 122-9 1/1/2013
  • Mishra A, Liu S, Sams GH, Curphey DP, Santhanam R, Rush LJ, Schaefer D, Falkenberg LG, Sullivan L, Jaroncyk L, Yang X, Fisk H, Wu LC, Hickey C, Chandler JC, Wu YZ, Heerema NA, Chan KK, Perrotti D, Zhang J, Porcu P, Racke FK, Garzon R, Lee RJ, Marcucci G, Caligiuri MAAberrant overexpression of IL-15 initiates large granular lymphocyte leukemia through chromosomal instability and DNA hypermethylation.Cancer Cell 22(5) 645-55 11/13/2012
  • Yu B, Hsu SH, Zhou C, Wang X, Terp MC, Wu Y, Teng L, Mao Y, Wang F, Xue W, Jacob ST, Ghoshal K, Lee RJ, Lee LJLipid nanoparticles for hepatic delivery of small interfering RNA.Biomaterials 33(25) 5924-34 9/1/2012
  • Tenchov B, Sugimoto Y, Koynova R, Brueggemeier RW, Lee RJHighly efficient cationic ethylphosphatidylcholine siRNA carrier for GFP suppression in modified breast cancer cells.Anticancer Res 32(7) 2563-6 7/1/2012
  • Zhou C, Mao Y, Sugimoto Y, Zhang Y, Kanthamneni N, Yu B, Brueggemeier RW, Lee LJ, Lee RJSPANosomes as delivery vehicles for small interfering RNA (siRNA).Mol Pharm 9(2) 201-10 2/6/2012
  • Huo T, Barth RF, Yang W, Nakkula RJ, Koynova R, Tenchov B, Chaudhury AR, Agius L, Boulikas T, Elleaume H, Lee RJPreparation, biodistribution and neurotoxicity of liposomal cisplatin following convection enhanced delivery in normal and F98 glioma bearing rats.PLoS One 7(11) e48752 1/1/2012
  • Zhou X, Zhang M, Yung B, Li H, Zhou C, Lee LJ, Lee RJLactosylated liposomes for targeted delivery of doxorubicin to hepatocellular carcinoma.Int J Nanomedicine 7 5465-74 1/1/2012
  • Li H, Piao L, Xu P, Ye W, Zhong S, Lin SH, Kulp SK, Mao Y, Cho Y, Lee L, Lee RJ, Lin YCLiposomes containing (-)-gossypol-enriched cottonseed oil suppress Bcl-2 and Bcl-xL expression in breast cancer cells.Pharm Res 28(12) 3256-64 12/1/2011