Mark Wewers D MD

Mark Wewers D MD
ProfessorCollege of Medicinewewers.2@osu.edu
201 Davis Heart & Lung Research Inst 473 W 12th Avenue Columbus Ohio 43210
Phone:614-247-7707Fax: (614) 293-4799
  • Molecular Carcinogenesis and Chemoprevention

General Research Interest

innate host responses of macrophages

Research Description

Dr. Wewer’s research focuses on host defense against pathogens, particularly relevant to the lung and critical to survival His lab is interested in understanding the role of proteins that regulate the activation of the intracellular enzyme, caspase-1. This work is relevant to understanding how the lung and circulating mononuclear phagocytes are capable of sensing danger from pathogens and responding with robuts inflammation centered around IL-1.

Transinstitutional Work

These innate immune projects are linked to the Center for Microbial Interface Biology, the Davis Heart and Lung Research Institute and the Comprehensive Cancer Center.  We currently work with CMIB members on a project understanding the host reponse to the intracellular pathogen, Francisella tularensis, we are actively pursuing the role of the inflammasome (caspase-1 regulatory proteins) in the context of acute myeloid leukemias with members of the CCC and we have several ongoing projects that are involved in the inflammasome response to sepsis and ventilator associated pneumonia.

Current Publications

  • Ghonime MG, Shamaa OR, Das S, Eldomany RA, Fernandes-Alnemri T, Alnemri ES, Gavrilin MA, Wewers MDInflammasome priming by lipopolysaccharide is dependent upon ERK signaling and proteasome function.J Immunol 192 3881-8 4/15/2014
  • Rahman MA, Sundaram K, Mitra S, Gavrilin MA, Wewers MDReceptor interacting protein-2 plays a critical role in human lung epithelial cells survival in response to Fas-induced cell-death.PLoS One 9 e92731 1/1/2014
  • Exline MC, Justiniano S, Hollyfield JL, Berhe F, Besecker BY, Das S, Wewers MD, Sarkar AMicrovesicular caspase-1 mediates lymphocyte apoptosis in sepsis.PLoS One 9 e90968 1/1/2014
  • Wewers MD, Crystal RGAlpha-1 antitrypsin augmentation therapy.COPD 10 Suppl 1 64-7 3/1/2013
  • Liu MJ, Bao S, Gálvez-Peralta M, Pyle CJ, Rudawsky AC, Pavlovicz RE, Killilea DW, Li C, Nebert DW, Wewers MD, Knoell DLZIP8 regulates host defense through zinc-mediated inhibition of NF-κB.Cell Rep 3 386-400 2/21/2013
  • Gavrilin MA, Besecker BY, Sarkar A, Knoell DL, Cormet-Boyaka E, Wewers MD, Butchar JP, Tridandapani S, Gillette DD, Shah PA, Cremer TAnalysis of human bronchial epithelial cell proinflammatory response to Burkholderia cenocepacia infection: inability to secrete il-1β.J Biol Chem 288 3691-5 2/8/2013
  • Ghonime MG, Shamaa OR, Eldomany RA, Gavrilin MA, Wewers MDTyrosine phosphatase inhibition induces an ASC-dependent pyroptosis.Biochem Biophys Res Commun 425 384-9 8/24/2012

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu